Zeyda Maximilan, Stulnig Thomas M
Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria.
Prog Lipid Res. 2006 May;45(3):187-202. doi: 10.1016/j.plipres.2006.01.002. Epub 2006 Feb 6.
The model of membrane compartmentalization by self-organizing functional lipid microdomains, named lipid rafts, has been a fruitful concept resulting in great progress in understanding T cell signal transduction. However, due to recent results it has become clear that lipid rafts describe only one out of several membrane organizing principles crucial for T cell activation besides fences and pickets and protein-protein interactions that take part in the formation of the immunological synapse as a highly organized structure at the T cell contact site to the antigen-presenting cell. This review describes the concepts of lipid rafts and other membrane organizing principles to evolve a novel integrated model on the functional role of microdomains in immunological synapse formation and T cell activation. Further research has to elucidate the relative contribution and interrelation of different modes of membrane organization in productive T cell activation.
由自组织功能性脂质微区形成的膜区室化模型，即脂筏，是一个卓有成效的概念，在理解T细胞信号转导方面取得了巨大进展。然而，基于最近的研究结果，很明显脂筏只是对T细胞激活至关重要的几种膜组织原则之一，除此之外还有栅栏和桩子以及参与免疫突触形成的蛋白质-蛋白质相互作用，免疫突触是T细胞与抗原呈递细胞接触部位形成的高度有序结构。本综述描述了脂筏和其他膜组织原则的概念，以发展一种关于微区在免疫突触形成和T细胞激活中的功能作用的新型综合模型。进一步的研究必须阐明不同膜组织模式在有效的T细胞激活中的相对贡献和相互关系。
