Szendi István, Kiss Marianna, Racsmány Mihály, Boda Krisztina, Cimmer Csongor, Vörös Erika, Kovács Zoltán A, Szekeres György, Galsi Gabriella, Pléh Csaba, Csernay László, Janka Zoltán
Department of Psychiatry, University of Szeged, Hungary.
Psychiatry Res. 2006 Jun 30;147(1):47-55. doi: 10.1016/j.pscychresns.2005.05.014. Epub 2006 Mar 20.
Thirteen male patients with schizophrenia and thirteen male normal control subjects were compared by magnetic resonance imaging (MRI) on volumes of the straight gyrus (SG), anterior cingulate gyrus, middle frontal gyrus, hippocampus, third ventricle, cavum septi pellucidi, total brain volume and intracranial volume. In addition, neuropsychological tasks were used to measure working memory and executive functions. Healthy volunteers and schizophrenic patients showed no significant differences in mean values for volumes of regions of interests. In the case of the SG, we found a significant difference in laterality: the tendency toward left dominance in healthy volunteers changed to significant right dominance in patients. The schizophrenic patients showed lower performance in working memory tasks, and strongly significant group differences were observed in measures of neurological signs assessed by the Neurological Evaluation Scale (NES). Negative symptoms correlated with the level of spatial working memory and executive functions. Negative symptoms also correlated with the volume of the right hippocampus, while the rate of anhedonia negatively correlated with the relative volume of the left SG.
通过磁共振成像（MRI）对13名男性精神分裂症患者和13名男性正常对照者的直回（SG）、前扣带回、额中回、海马体、第三脑室、透明隔腔、全脑体积和颅内体积进行了比较。此外，还使用神经心理学任务来测量工作记忆和执行功能。健康志愿者和精神分裂症患者在感兴趣区域体积的平均值上没有显著差异。在SG的情况下，我们发现了明显的偏侧性差异：健康志愿者中左侧优势的倾向在患者中转变为明显的右侧优势。精神分裂症患者在工作记忆任务中的表现较低，并且在通过神经评估量表（NES）评估的神经体征测量中观察到了显著的组间差异。阴性症状与空间工作记忆和执行功能水平相关。阴性症状也与右侧海马体的体积相关，而快感缺乏率与左侧SG的相对体积呈负相关。
