利用水痘-带状疱疹病毒的基因组分析来调查肾内科内疑似水痘-带状疱疹病毒的传播情况。
Use of genomic analysis of varicella-zoster virus to investigate suspected varicella-zoster transmission within a renal unit.
作者信息
Molyneaux P J, Parker S, Khan I H, Millar C G M, Breuer J
机构信息
Department of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK.
出版信息
J Clin Virol. 2006 May;36(1):76-8. doi: 10.1016/j.jcv.2005.12.012. Epub 2006 Mar 20.
BACKGROUND
The source of hospital-acquired chickenpox infection may be presumed from a known exposure, but has not been previously proven using genomic analysis.
OBJECTIVE
Investigation of suspected VZV transmission was done using single nucleotide polymorphism genomic analysis.
STUDY DESIGN
Comparison was made of viral isolates from two patients with chickenpox on the same ward who were not known to have had direct contact.
RESULTS
An identical genotype in the variable R1 region of the VZV was isolated from the two patients.
CONCLUSION
Inapparent hospital-acquired transmission was the most likely route of infection.
背景
医院获得性水痘感染源可根据已知接触情况推测，但此前尚未通过基因组分析得到证实。
目的
采用单核苷酸多态性基因组分析对疑似水痘带状疱疹病毒（VZV）传播进行调查。
研究设计
对同一病房两名未知有直接接触的水痘患者的病毒分离株进行比较。
结果
从两名患者中分离出VZV可变R1区域相同的基因型。
结论
隐匿性医院获得性传播很可能是感染途径。
Zotero 插件