Quinlivan M, Sengupta N, Breuer J
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts, and the London School of Medicine and Dentistry, Queen Mary College, London E1 2AT, UK.
J Clin Virol. 2009 Jan;44(1):66-9. doi: 10.1016/j.jcv.2008.09.004. Epub 2008 Nov 7.
We describe for the first time a case of varicella caused by co-infection with 2 genotypes of Varicella-zoster virus in a 19 month old child 3 days post-immunization with the varicella live vaccine. The presence of 2 different wild-type viruses in vesicular fluid was confirmed by amplification from single virus genomes and genotyping of single nucleotide polymorphisms (SNPs) known to distinguish the 5 different genotypes of VZV. The finding has important implications for recombination of wild type VZV.
我们首次描述了一例19个月大的儿童在接种水痘活疫苗3天后，因感染两种水痘-带状疱疹病毒基因型而引发水痘的病例。通过从单个病毒基因组进行扩增以及对已知可区分水痘-带状疱疹病毒5种不同基因型的单核苷酸多态性（SNP）进行基因分型，证实了水疱液中存在两种不同的野生型病毒。这一发现对野生型水痘-带状疱疹病毒的重组具有重要意义。
