Godlewska Renata, Dzwonek Artur, Mikuła Michał, Ostrowski Jerzy, Pawłowski Marcin, Bujnicki Janusz M, Jagusztyn-Krynicka Elzbieta K
Department of Bacterial Genetics, Institute of Microbiology, Warsaw University, Miecznikowa 1, PL-02-096 Warsaw, Poland.
Int J Med Microbiol. 2006 Aug;296(4-5):321-4. doi: 10.1016/j.ijmm.2005.11.010. Epub 2006 Mar 20.
Dsb proteins control the formation and rearrangement of disulfide bonds during the folding of membrane and exported proteins. Here we examined the role of DsbI protein in Helicobacter pylori pathogenesis and demonstrated that a dsbI mutant impaired in disulfide bond formation revealed a greatly reduced ability to colonize mice gastric mucosa.
Dsb蛋白在膜蛋白和分泌蛋白折叠过程中控制二硫键的形成和重排。在此，我们研究了DsbI蛋白在幽门螺杆菌致病机制中的作用，并证明二硫键形成受损的dsbI突变体在小鼠胃黏膜定植的能力大大降低。
