Kaakoush Nadeem O, Kovach Zsuzsanna, Mendz George L
School of Medical Sciences, The University of New South Wales, Sydney, Australia.
FEMS Immunol Med Microbiol. 2007 Jul;50(2):177-83. doi: 10.1111/j.1574-695X.2007.00259.x. Epub 2007 May 22.
Helicobacter pylori infections are responsible for a sequence of molecular events which ultimately result in the development of gastric diseases. The pathogenesis of H. pylori has been studied extensively with strong focus on the identification of virulence factors. In contrast, the involvement of thiol:disulfide oxidoreductases in bacterial pathogenesis is less well understood. This paper provides a review of the current knowledge of H. pylori putative thiol:disulfide oxidoreductases, and their potential role in promoting virulence and colonization. Several bioinformatic analyses served to complete the information on these oxidoreductases of H. pylori.
幽门螺杆菌感染引发了一系列分子事件，最终导致胃部疾病的发生。人们对幽门螺杆菌的发病机制进行了广泛研究，重点在于鉴定毒力因子。相比之下，硫醇：二硫键氧化还原酶在细菌发病机制中的作用尚不太清楚。本文综述了目前关于幽门螺杆菌假定硫醇：二硫键氧化还原酶的知识，以及它们在促进毒力和定植方面的潜在作用。多项生物信息学分析完善了有关幽门螺杆菌这些氧化还原酶的信息。
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