复杂区域疼痛综合征中B19微小病毒IgG血清阳性率增加与抗内皮自身免疫无关。

Increased seroprevalence of parvovirus B 19 IgG in complex regional pain syndrome is not associated with antiendothelial autoimmunity.

作者信息

Gross Oliver, Tschernatsch Marlene, Bräu Michael E, Hempelmann Gunter, Birklein Frank, Kaps Manfred, Madlener Katharina, Blaes Franz

机构信息

Department of Neurology, Justus-Liebig-University, Am Steg 14, 35385 Giessen, Germany.

出版信息

Eur J Pain. 2007 Feb;11(2):237-40. doi: 10.1016/j.ejpain.2006.01.006. Epub 2006 Mar 20.

DOI:10.1016/j.ejpain.2006.01.006

PMID:16545972

Abstract

The etiology of complex regional pain syndrome (CRPS) is unclear yet. Recently autoantibodies and antecedent viral infections have been discussed to be involved in the pathogenesis of CRPS. We investigated sera from 39 CRPS patients and healthy controls for parvovirus B19 IgG and the occurrence of antiendothelial autoantibodies (AECA). CRPS patients showed a higher seroprevalence of parvovirus B19 IgG than controls (p < 0.01). All CRPS 2 patients were positive. 10.2% of the CRPS patients and 10.0% of the controls had AECA (n.s.) and AECA were not associated with parvovirus B19 seropositivity. Our findings suggest the involvement of parvovirus B19, but not autoantibody-mediated endothelial cell damage, in the pathogenesis of CRPS.

摘要

复杂性区域疼痛综合征（CRPS）的病因尚不清楚。最近，自身抗体和先前的病毒感染被认为与CRPS的发病机制有关。我们检测了39例CRPS患者和健康对照者血清中的细小病毒B19 IgG以及抗内皮细胞自身抗体（AECA）的情况。CRPS患者细小病毒B19 IgG的血清阳性率高于对照组（p < 0.01）。所有CRPS 2型患者均为阳性。10.2%的CRPS患者和10.0%的对照者有AECA（无统计学差异），且AECA与细小病毒B19血清阳性无关。我们的研究结果提示细小病毒B19参与了CRPS的发病机制，但自身抗体介导的内皮细胞损伤并非如此。