Pugliese Agostino, Beltramo Tiziana, Torre Donato, Roccatello Dario
Department of Medical and Surgical Sciences, Clinical Microbiology University of Turin, Amedeo di Savoia Hospital, Turin, Italy.
Cell Biochem Funct. 2007 Nov-Dec;25(6):639-41. doi: 10.1002/cbf.1364.
Parvovirus B19 (PVB19) is the causative agent of erythema infectiosum and sometimes the infection is correlated with severe haematological complications, or in pregnancy to fetalis hydrops. Moreover some authors suggest an infection involvement in some autoimmune diseases. To this purpose we evaluated seroprevalence for PVB19 in following the autoimmune or dysreactive pathologies: systemic lupus erythematosus (SLE), cryoglobulinemia, idiopathic systemic--ANCA associated vasculitis, rheumatoid arthritis (RA). In the case of LES, 31/42 patients were positive for PVB19 versus 21/42 of blood donors, as controls subjects (73.8% vs. 50%; significant difference for p < 0.05), moreover a significant difference for p < 0.001 was detected comparing mean titre values of IgGs against PVB19 of two groups (UI 1.94 +/- 0.90 vs. 1.24 +/- 0.80). In contrast no significant differences were found in the case of percent seropositivity of cryoglobulinemic subjects (37/57 = 64.9%, the majority of whom were HCV+) in comparison with the control group (50%). However mean units index (UI) was 1.63 +/- 0.81; p = 0.019 versus the control group. Similar result, with regard to the percentage of seropositivity, was found for vasculitis (9/17 = 52.9%). The data reported here can confirm a possible correlation between PVB19 prior infection and LES and also suggest possible implications in the case of cryoglobulinemia. In fact, most of our patients were affected by a nephropathic or systemic form of HCV+ cryoglobulinemia and the presence of other infective cofactors could be suggestive in the evolution of this clinical situation.
细小病毒B19（PVB19）是传染性红斑的病原体，有时该感染与严重血液学并发症相关，或在孕期与胎儿水肿相关。此外，一些作者认为该感染与某些自身免疫性疾病有关。为此，我们评估了PVB19在以下自身免疫性或反应异常性疾病中的血清流行率：系统性红斑狼疮（SLE）、冷球蛋白血症、特发性系统性——抗中性粒细胞胞浆抗体（ANCA）相关血管炎、类风湿关节炎（RA）。在SLE病例中，42例患者中有31例PVB19呈阳性，而作为对照的42例献血者中有21例呈阳性（73.8%对50%；p<0.05有显著差异），此外，比较两组针对PVB19的IgG平均滴度值时，检测到p<0.001有显著差异（单位指数[UI]1.94±0.90对1.24±0.80）。相比之下，冷球蛋白血症患者的血清阳性率（37/57 = 64.9%，其中大多数为丙型肝炎病毒[HCV]阳性）与对照组（50%）相比未发现显著差异。然而，平均单位指数（UI）为1.63±0.81；与对照组相比p = 0.019。血管炎患者的血清阳性率（9/17 = 52.9%）也得到了类似结果。此处报告的数据可以证实PVB19既往感染与SLE之间可能存在关联，也提示了冷球蛋白血症情况下可能的影响。事实上，我们的大多数患者患有肾病性或全身性HCV阳性冷球蛋白血症，其他感染性辅助因子的存在可能提示这种临床情况的演变。
