Zancanaro Pedro C Queiroz, McGirt Laura Y, Mamelak Adam J, Nguyen Ruby H-N, Martins Ciro R
Faculdade de Medicina, Universidade de Brasilia, Brazil.
J Am Acad Dermatol. 2006 Apr;54(4):581-8. doi: 10.1016/j.jaad.2005.12.030. Epub 2006 Feb 23.
Widespread introduction of highly active antiretroviral therapy (HAART) in the mid 1990s has altered the presentation of the cutaneous manifestations associated with HIV infection.
Our purpose was to evaluate the use of HAART on the prevalence and spectrum of cutaneous manifestations in HIV-infected patients.
A study of the initial visits of 897 HIV-infected patients at an urban dermatology clinic between 1996 and 2002 was performed.
Folliculitis was the most common cutaneous disorder identified. Patients with CD4-positive cell counts less than 200 cells/mm3 had an increased prevalence of folliculitis and prurigo nodularis, whereas those with HIV viral loads higher than 55,000 copies/mL had a higher prevalence of idiopathic pruritus and candidiasis. Patients not receiving HAART had increased rates of folliculitis and prurigo nodularis. Patients receiving HAART had increased rates of photosensitivity and molluscum contagiosum.
This was a cross-sectional study in which temporality was unable to be determined.
With ongoing therapeutic advancements, the cutaneous manifestations associated with HIV infection will continue to evolve.
20世纪90年代中期高效抗逆转录病毒疗法（HAART）的广泛应用改变了与HIV感染相关的皮肤表现。
我们的目的是评估HAART对HIV感染患者皮肤表现的患病率和范围的影响。
对1996年至2002年间在一家城市皮肤科诊所初诊的897例HIV感染患者进行了研究。
毛囊炎是最常见的皮肤疾病。CD4阳性细胞计数低于200个细胞/mm³的患者毛囊炎和结节性痒疹的患病率增加，而HIV病毒载量高于55,000拷贝/mL的患者特发性瘙痒和念珠菌病的患病率更高。未接受HAART的患者毛囊炎和结节性痒疹的发生率增加。接受HAART的患者光敏性和传染性软疣的发生率增加。
这是一项横断面研究，无法确定时间顺序。
随着治疗的不断进步，与HIV感染相关的皮肤表现将继续演变。
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