选择性组胺H3受体配体对大鼠催乳素和生长激素分泌的影响。

Effects of selective histamine H3-receptor ligands on prolactin and growth hormone secretion in the rat.

作者信息

Netti C, Guidobono F, Sibilia V, Pagani F, Villa I, Pecile A

机构信息

Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy.

出版信息

Agents Actions. 1991 May;33(1-2):147-9. doi: 10.1007/BF01993151.

DOI:10.1007/BF01993151

PMID:1654733

Abstract

The effects of intracarotid (i.a.) administration of the histamine (HA) H3-receptor agonist (R)-alpha-methyl-histamine (alpha MeHA) and of the H3-antagonist thioperamide, (THIO) on basal or morphine (M)-induced prolactin (PRL) and growth hormone (GH) secretion were studied in male rats. M was administered 3 h after the H3-drugs. Neither THIO (2.5 mg/kg) nor alpha MeHA (10 mg/kg) changed basal PRL levels and only THIO enhanced the PRL-releasing effect of M (6 mg/kg). Basal GH secretion was not modified by THIO. alpha MeHA slightly increased GH secretion. THIO significantly decreased M-stimulated GH secretion (1 mg/kg, i.a.) and alpha MeHA slightly increased it. These results, in agreement with previous evidence obtained after central HA administration, indicated that endogenous brain HA facilitates PRL and inhibits GH secretion.

摘要

在雄性大鼠中研究了经颈内动脉（i.a.）注射组胺（HA）H3受体激动剂（R）-α-甲基组胺（αMeHA）和H3拮抗剂硫代哌啶（THIO）对基础或吗啡（M）诱导的催乳素（PRL）和生长激素（GH）分泌的影响。在给予H3药物3小时后给予M。THIO（2.5毫克/千克）和αMeHA（10毫克/千克）均未改变基础PRL水平，只有THIO增强了M（6毫克/千克）的PRL释放作用。THIO未改变基础GH分泌。αMeHA略微增加了GH分泌。THIO显著降低了M刺激的GH分泌（1毫克/千克，i.a.），而αMeHA则使其略有增加。这些结果与先前经中枢给予HA后获得的证据一致，表明内源性脑HA促进PRL分泌并抑制GH分泌。