脑组胺在大鼠催乳素基础分泌及应激诱导分泌中的作用。

Involvement of brain histamine in basal and stress-induced release of prolactin in the rat.

作者信息

Netti C, Guidobono F, Sibilia V, Villa I, Cazzamalli E, Pecile A

出版信息

Agents Actions. 1987 Apr;20(3-4):236-8. doi: 10.1007/BF02074679.

DOI:10.1007/BF02074679

Abstract

We investigated whether inhibition of brain histamine (HA) synthesis by alpha-fluoromethylhistidine (alpha-FMH) can influence basal or stimulated prolactin (PRL) release in male rats. alpha-FMH was administered either into the carotid (i.a., 20 and 100 mg/kg) or intracerebroventricularly (i.c.v., 200 micrograms/rat) into freely moving rats with indwelling catheters. Plasma PRL levels were measured 90, 120, 180 min later. Both i.a. and i.c.v. administration of alpha-FMH significantly inhibited basal PRL secretion at 120 and 180 min. When PRL secretion was stimulated by exposing rats to restraint stress, alpha-FMH administered 3 h before the stress (20 and 100 mg/kg, i.a.; 200 micrograms/rat, i.c.v.) was able to prevent the PRL surges at 10 and 20 min after stress. These results suggest that endogenous brain HA has a facilitatory role in the control of PRL secretion in rats.

摘要

我们研究了α-氟甲基组氨酸（α-FMH）对脑内组胺（HA）合成的抑制作用是否会影响雄性大鼠基础状态下或受刺激时催乳素（PRL）的释放。将α-FMH通过颈动脉注射（i.a.，20和100mg/kg）或脑室内注射（i.c.v.，200μg/只大鼠）给予带有留置导管的自由活动大鼠。在90、120、180分钟后测量血浆PRL水平。α-FMH的颈动脉注射和脑室内注射在120和180分钟时均显著抑制基础PRL分泌。当通过束缚应激刺激大鼠的PRL分泌时，在应激前3小时给予α-FMH（20和100mg/kg，i.a.；200μg/只大鼠，i.c.v.）能够在应激后10和20分钟时阻止PRL的激增。这些结果表明内源性脑HA在大鼠PRL分泌的调控中具有促进作用。