Axer-Siegel R, Bourla D, Kremer I, Weinberger D, Snir M
Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petach Tikva 49 100, Israel.
Br J Ophthalmol. 2006 Apr;90(4):491-5. doi: 10.1136/bjo.2005.082768.
To evaluate and compare the effects of peripheral retinal cryotherapy and diode laser photocoagulation on axial length, anterior chamber depth, and lens thickness in developing rabbit eyes.
26 eyes of 6 week old Abbit rabbits were randomly assigned to undergo laser photocoagulation or cryotherapy of the peripheral retina. Eight eyes of four untreated rabbits served as controls. Biometric and intraocular pressure measurements were performed at 0, 5, and 10 weeks after treatment.
Five rabbits died, leaving 10 rabbits (20 eyes) in the study group and two (four eyes) in the control group. Average axial lengths for the control, laser treated, and cryo treated eyes were 15.72 mm, 16.08 mm, and 16.11 mm, respectively, at baseline and 17.48 mm, 18.09 mm, and 19.4 mm, respectively, at 10 weeks after treatment (p = 0.028, paired Wilcoxon test). Anterior chamber depth increased from 2.2 mm to 2.5 mm in both treatment groups, and from 2.14 mm to 2.28 mm in the control group. Lens thickness averaged 5.11 mm in the control group and 5.38 mm in the treatment groups before treatment, and 6.34 mm, 6.31 mm, and 6.38 mm, respectively, 10 weeks after treatment.
Peripheral retinal cryotherapy causes a significantly greater elongation of the eye compared to diode laser photocoagulation in a rabbit model.
评估并比较周边视网膜冷冻疗法和二极管激光光凝术对发育中兔眼眼轴长度、前房深度和晶状体厚度的影响。
将6周龄兔的26只眼随机分为接受周边视网膜激光光凝术或冷冻疗法两组。4只未治疗兔的8只眼作为对照。在治疗后0、5和10周进行生物测量和眼压测量。
5只兔死亡，研究组剩下10只兔（20只眼），对照组剩下2只兔（4只眼）。治疗前，对照组、激光治疗组和冷冻治疗组的平均眼轴长度分别为15.72mm、16.08mm和16.11mm，治疗后10周分别为17.48mm、18.09mm和19.4mm（配对Wilcoxon检验，p = 0.028）。两个治疗组的前房深度从2.2mm增加到2.5mm，对照组从2.14mm增加到2.28mm。治疗前，对照组晶状体平均厚度为5.11mm，治疗组为5.38mm，治疗后10周，分别为6.34mm、6.31mm和6.38mm。
在兔模型中，与二极管激光光凝术相比，周边视网膜冷冻疗法导致眼轴显著更长。
