Nilsson G, Alving K, Lundberg J M, Ahlstedt S
Dept. of Allergy and Immunology, Pharmacia Diagnostics AB, Uppsala, Sweden.
Allergy. 1991 May;46(4):304-11. doi: 10.1111/j.1398-9995.1991.tb00589.x.
The interaction between the nervous system, immune system and bronchial reactivity was studied in rats by using the neurotoxin capsaicin. Rats were treated with capsaicin at 1-2 days of age or at adult age, before or after sensitization by subcutaneous injections with ovalbumin (OA). The levels of the neuropeptides neurokinin A and calcitonin gene-related peptide were decreased in the lung after capsaicin treatment, as determined with radioimmunoassay, whereas the levels of neuropeptide Y were unaffected. The levels of IgA, IgE and IgG in bronchial lavage were also affected by capsaicin treatment; however, the results were heterogeneous. Capsaicin treatment after sensitization reduced the bronchial reactivity to challenge with OA aerosol and serotonin iv. The results demonstrated that reduction of neuropeptide levels with capsaicin affected both bronchial reactivity and the levels of antibodies in bronchial lavage fluid. However, no correlation between these two parameters was seen, demonstrating the complexity of the system.
利用神经毒素辣椒素，在大鼠中研究了神经系统、免疫系统与支气管反应性之间的相互作用。在1-2日龄或成年时，通过皮下注射卵清蛋白（OA）致敏之前或之后，用辣椒素处理大鼠。用放射免疫分析法测定，辣椒素处理后肺中神经肽A和降钙素基因相关肽的水平降低，而神经肽Y的水平未受影响。支气管灌洗中IgA、IgE和IgG的水平也受辣椒素处理的影响；然而，结果并不一致。致敏后用辣椒素处理可降低支气管对OA气雾剂激发和静脉注射5-羟色胺的反应性。结果表明，用辣椒素降低神经肽水平会影响支气管反应性和支气管灌洗液中的抗体水平。然而，未观察到这两个参数之间的相关性，这表明该系统的复杂性。
