Nilsson G, Alving K, Lundberg J M, Ahlstedt S
Department of Allergy and Immunology, Pharmacia Diagnostics, Uppsala, Sweden.
Int Arch Allergy Appl Immunol. 1989;88(1-2):234-6. doi: 10.1159/000234795.
Treatment of ovalbumin-sensitized rats with capsaicin resulted in altered bronchial reactivity to both ovalbumin and serotonin. The increase in bronchial reactivity to ovalbumin in neonatally capsaicin-treated rats compared to animals only sensitized may be influenced by the changed ratios of IgA, IgE, and IgG antibodies, together with the inflammation in the lung. Thus, capsaicin given neonatally inhibited the formation of antibodies, both specific titers and total levels, in bronchial lavage.
用辣椒素处理卵清蛋白致敏的大鼠会导致支气管对卵清蛋白和血清素的反应性发生改变。与仅致敏的动物相比，新生期用辣椒素处理的大鼠对卵清蛋白的支气管反应性增加可能受到IgA、IgE和IgG抗体比例变化以及肺部炎症的影响。因此，新生期给予辣椒素会抑制支气管灌洗中抗体的形成，包括特异性滴度和总水平。
