Alving K, Ulfgren A K, Lundberg J M, Ahlstedt S
Int Arch Allergy Appl Immunol. 1987;82(3-4):377-9. doi: 10.1159/000234231.
The involvement of tachykinins in the airway reactivity of ovalbumin (OA)-sensitized rats was studied by capsaicin (CAPS) treatment. In subcutaneously sensitized animals, the reactivity to both OA aerosol and serotonin given intravenously was decreased when CAPS was given after the sensitization period. No effects on the serum IgE and IgG antibody levels were seen in these animals. In contrast, when CAPS was given before the sensitization period, no effects were seen on the OA aerosol and serotonin reactivities. Immunohistochemical examination revealed that the Ia antigen expression in the bronchial epithelium was increased by both subcutaneous and aerosol sensitization. The CAPS treatment decreased this Ia antigen expression. Histological examination of mononuclear cells, mast cells and goblet cells revealed only small effects on the cell numbers by both the OA sensitization and the CAPS treatment. The results demonstrate a link between tachykinins, serotonin, the immune system and clinical lung reactivity. The mechanisms for this seem to be complex, since the timing of the CAPS treatment and antigen sensitization is crucial for the outcome.
通过辣椒素（CAPS）处理研究速激肽在卵清蛋白（OA）致敏大鼠气道反应性中的作用。在皮下致敏的动物中，致敏期后给予CAPS时，对静脉注射的OA气雾剂和血清素的反应性均降低。在这些动物中未观察到对血清IgE和IgG抗体水平的影响。相反，在致敏期前给予CAPS时，对OA气雾剂和血清素反应性未观察到影响。免疫组织化学检查显示，皮下和气雾剂致敏均使支气管上皮中的Ia抗原表达增加。CAPS处理降低了这种Ia抗原表达。对单核细胞、肥大细胞和杯状细胞的组织学检查显示，OA致敏和CAPS处理对细胞数量的影响均较小。结果表明速激肽、血清素、免疫系统与临床肺反应性之间存在联系。其机制似乎很复杂，因为CAPS处理和抗原致敏的时机对结果至关重要。
