Kobak Senol, Kobak Arzu Celebi, Kabasakal Yasemin, Doganavsargil Eker
Section of Rheumatology, Department of Medicine, Ege University School of Medicine, Bornova, Izmir, Turkey.
Clin Rheumatol. 2007 Feb;26(2):173-5. doi: 10.1007/s10067-006-0255-9.
There are few reports about the coexistence of Sjögren's syndrome (SS) and ankylosing spondylitis (AS). To evaluate the frequency of SS in patients with AS. We studied 70 patients with AS presenting to the university outpatient clinic between January 2002 and November 2003. All the patients were asked about sicca symptoms by using sicca questionnaire. Rheumatoid factor, anti-nuclear antibody, anti-Ro, and anti-La antibodies were examined for each of the patients. Salivary flowmetry for the existence of xerostomia, Schirmer's test, and break-up time for the existence of xerophtalmia were performed in all patients with AS. Minor salivary gland biopsy was performed on the patients with at least three positive responses to the sicca questionnaire and positive xerostomia/xerophtalmia tests. Biopsies were regarded as pathological when they showed focal grade iii and grade IV sialoadenitis according to Chisholm grading criteria. Among 70 AS cases, 56 (80%) were men, 14 (20%) were women, and the mean age was 42 years old. Minor salivary gland biopsy was performed on the 16 patients. Of 16 minor salivary gland biopsies, 7 were assessed as pathological--5 of them showed grade III, and 2 of them showed grade IV sialoadenitis. Of these seven patients, one was anti-Ro-positive, and two were anti-La-positive. There was no patient with normal salivary gland biopsy and anti-Ro and/or anti-La positivity. In our study group, 7 (10%) of 70 AS patients had concomitant SS. Therefore, it seems likely that AS may have pathogenetic association with SS.
关于干燥综合征（SS）与强直性脊柱炎（AS）共存的报道较少。为评估AS患者中SS的发生率，我们研究了2002年1月至2003年11月期间到大学门诊就诊的70例AS患者。通过使用干燥问卷询问所有患者的口干症状。对每位患者检测类风湿因子、抗核抗体、抗Ro和抗La抗体。对所有AS患者进行唾液流量测定以检测是否存在口干症，进行Schirmer试验以及检测泪膜破裂时间以检测是否存在干眼症。对干燥问卷至少有三项阳性反应且口干症/干眼症检测呈阳性的患者进行小唾液腺活检。根据Chisholm分级标准，当活检显示局灶性III级和IV级涎腺炎时，视为病理活检。70例AS病例中，男性56例（80%），女性14例（20%），平均年龄42岁。对16例患者进行了小唾液腺活检。16例小唾液腺活检中，7例被评估为病理活检——其中5例显示III级，2例显示IV级涎腺炎。在这7例患者中，1例抗Ro阳性，2例抗La阳性。没有小唾液腺活检正常且抗Ro和/或抗La阳性的患者。在我们的研究组中，70例AS患者中有7例（10%）合并SS。因此，AS似乎可能与SS存在发病机制上的关联。
