Lian Fang, Liu Hai-ping, Wang Yun-xia
Reproductive Center, Hospital Affliated to Shandong University of Traditional Chinese Medicine, Jinan 250011.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Feb;26(2):110-3.
To observe the mechanism of Quyujiedu (QYJD, a method for removing stasis and detoxicating) in treating endometriosis of stasis-toxic syndrome type.
Clinical study: Sixty patients were randomly divided into two groups, the treated group treated with QYJD and the control group treated with Danazol. The changes of clinical symptoms, physical signs, pregnancy rate, as well as levels of interleukin-1 (IL-1), interleukin-6 (IL-6) and endometrial antibody (EMAb) in them before and after treatment were observed. Experimental study: Sixty rats were established into endometriosis model, and randomly divided into the QYJD treated group, the Danazol treated group for positive control and the untreated group for negative control to observe the expression of Bax.
Clinical study showed that in the treated group and the control group, after treatment, dysmenorrhea score were 2.40 +/- 1.85 and 3.47 +/- 2.03, the menoxenia score 1.67 +/- 2.04 and 3.73 +/- 1.72 (P < 0.05), and the pregnancy rate 63.2% and 23.5% respectively, the difference between them was significant (all P < 0.05). Both of the two treatments can rectify immunity, reduce levels of IL-1 and IL-6, and lower the positive rate of EMAb. Experimental study showed that QYJD could improve the expression of Bax in ectopic endometrium, but could not affect the on-side expression of Bax in endometrium and muscle tissue.
QYJD is effective in improving the stasis-toxic syndrome of endometriosis, its mechanism related with the regulation of the immune condition and the promotion of cell apoptosis in ectopic endometrium, indicating that QYJD is an effective remedy for endometriosis of stasis-toxic syndrome type.
观察祛瘀解毒法治疗瘀毒型子宫内膜异位症的作用机制。
临床研究：将60例患者随机分为两组，治疗组采用祛瘀解毒法治疗，对照组采用达那唑治疗。观察两组治疗前后临床症状、体征、妊娠率以及白细胞介素-1（IL-1）、白细胞介素-6（IL-6）和子宫内膜抗体（EMAb）水平的变化。实验研究：将60只大鼠建立子宫内膜异位症模型，随机分为祛瘀解毒法治疗组、达那唑阳性对照组和未治疗阴性对照组，观察Bax的表达。
临床研究显示，治疗组和对照组治疗后痛经评分分别为2.40±1.85和3.47±2.03，月经量评分分别为1.67±2.04和3.73±1.72（P<0.05），妊娠率分别为63.2%和23.5%，差异有统计学意义（均P<0.05）。两种治疗方法均能调节免疫，降低IL-1和IL-6水平，降低EMAb阳性率。实验研究显示，祛瘀解毒法可提高异位内膜中Bax的表达，但不影响在位内膜及肌组织中Bax的表达。
祛瘀解毒法能有效改善瘀毒型子宫内膜异位症，其机制与调节免疫状态及促进异位内膜细胞凋亡有关，提示祛瘀解毒法是治疗瘀毒型子宫内膜异位症的有效方药。
