Connelly J H, Robey-Cafferty S S, Cleary K R
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston.
Arch Pathol Lab Med. 1991 Oct;115(10):1022-5.
The significance of a large extracellular mucinous component in colorectal adenocarcinomas continues to be controversial. We studied 62 stage B and C mucinous carcinomas defined by 60% or greater mucinous component. Sixty of these patients had matched nonmucinous adenocarcinoma controls. Patients with mucinous carcinomas with a residual adenoma had a significantly greater survival than those who did not. Overall, no difference was noted in 5-year survival between patients with mucinous carcinoma and nonmucinous adenocarcinoma (64% each). However, when the stages were considered separately, patients with stage B mucinous carcinoma fared significantly worse and had more local sites of treatment failure. We speculate that patients with stage B mucinous carcinoma may have a worse prognosis owing to the extra-cellular mucin, which may make a complete surgical extirpation more difficult.
大肠腺癌中大量细胞外黏液成分的意义一直存在争议。我们研究了62例黏液成分占60%或更多的B期和C期黏液癌。其中60例患者有配对的非黏液腺癌对照。伴有残余腺瘤的黏液癌患者的生存期明显长于无残余腺瘤者。总体而言，黏液癌患者与非黏液腺癌患者的5年生存率无差异（均为64%）。然而，当分别考虑分期时，B期黏液癌患者预后明显更差，局部治疗失败部位更多。我们推测，B期黏液癌患者预后可能更差，原因是细胞外黏液可能使手术完全切除更加困难。
