Okuno M, Ikehara T, Nagayama M, Kato Y, Yui S, Umeyama K
First Department of Surgery, Osaka City University Medical School, Japan.
Am Surg. 1988 Nov;54(11):681-5.
Mucinous carcinomas accounted for 37 (6.4%) of 540 cases of colorectal carcinoma. The clinical and pathological features of these mucinous carcinomas were compared with those of the 510 well or moderately differentiated adenocarcinomas. Mucinous carcinoma was more common in the patients 39 years of age or under (P less than 0.05) and was more frequent in the female patients. A large number of mucinous carcinomas were located in the rectum, followed by the right colon. However, the right colon showed a higher relative incidence (40.5% vs 12.5%, P less than 0.005). Mucinous carcinoma was characterized by infiltration of the surrounding tissues (24.3% vs 7.8%, P less than 0.005), positive lymph node involvement (75.7% vs 48.6%, P less than 0.005), and peritoneal implant (21.6% vs 4.1%, P less than 0.005). The cumulative five and ten year survival rates after resection of mucinous carcinoma were 45.5 per cent and 39.8 per cent, respectively, and those after curative resection, 72.4 per cent and 63.5 per cent, respectively. These survival rates were lower, without significant differences, than those for the well or moderately differentiated adenocarcinomas. The results suggest the need for aggressive lymph node dissection and wide excision of the surrounding tissues for mucinous carcinoma, with special attention paid to local recurrence.
黏液腺癌占540例结直肠癌病例中的37例（6.4%）。将这些黏液腺癌的临床和病理特征与510例高分化或中分化腺癌的特征进行了比较。黏液腺癌在39岁及以下患者中更为常见（P<0.05），且在女性患者中更为频发。大量黏液腺癌位于直肠，其次是右半结肠。然而，右半结肠的相对发病率更高（40.5%对12.5%，P<0.005）。黏液腺癌的特征为周围组织浸润（24.3%对7.8%，P<0.005）、阳性淋巴结受累（75.7%对48.6%，P<0.005）和腹膜种植（21.6%对4.1%，P<0.005）。黏液腺癌切除术后的累积5年和10年生存率分别为45.5%和39.8%，根治性切除后的生存率分别为72.4%和63.5%。这些生存率低于高分化或中分化腺癌的生存率，但无显著差异。结果表明，对于黏液腺癌需要积极进行淋巴结清扫和广泛切除周围组织，并特别关注局部复发。
