Jimenez Victor H
Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Colonia seccion XVI, Tlalpan, DF, CP 14,000, México.
BMC Urol. 2006 Mar 20;6:10. doi: 10.1186/1471-2490-6-10.
Renal cell carcinoma is the most common kidney tumor in adults and accounts for approximately 3% of adult malignancies. An increased incidence of second malignancies has been well documented in a number of different disorders, such as head and neck tumors, and hairy cell leukemia. In addition, treatment associated second malignancies (usually leukemias and lymphomas but also solid tumors) have been described in long term survivors of Hodgkin's lymphoma (HL), Non Hodgkin's lymphoma and in various pediatric tumors.
We present the case of a 66 year-old woman with abdominal pain and dyspnea. We performed a thorax CT scan that showed lymph nodes enlargement and subsequently by presence of abdominal pain was performed an abdominal and pelvis CT scan that showed a right kidney tumor of 4 x 5 cms besides of abdominal lymph nodes enlargement. A radical right nephrectomy was designed and Hodgkin's lymphoma was diagnosed in the abdominal lymph nodes while renal cell tumor exhibited a renal cell cancer. Patient received EVA protocol achieving complete response.
We described the first case reported in the medical literature of the coexistence between Hodgkin's lymphoma and renal cell cancer. Previous reports have shown the relationship of lymphoid neoplasms with solid tumors, but they have usually described secondary forms of cancer related to chemotherapy.
肾细胞癌是成人中最常见的肾脏肿瘤，约占成人恶性肿瘤的3%。在许多不同疾病中，如头颈部肿瘤和毛细胞白血病，二次恶性肿瘤的发病率增加已有充分记录。此外，在霍奇金淋巴瘤（HL）、非霍奇金淋巴瘤的长期幸存者以及各种儿科肿瘤中，也描述了与治疗相关的二次恶性肿瘤（通常为白血病和淋巴瘤，但也有实体瘤）。
我们报告了一例66岁腹痛和呼吸困难的女性病例。我们进行了胸部CT扫描，显示淋巴结肿大，随后因腹痛进行了腹部和盆腔CT扫描，结果显示除腹部淋巴结肿大外，右肾有一个4×5厘米的肿瘤。设计了根治性右肾切除术，腹部淋巴结诊断为霍奇金淋巴瘤，而肾细胞肿瘤表现为肾细胞癌。患者接受EVA方案治疗后获得完全缓解。
我们描述了医学文献中首次报道的霍奇金淋巴瘤与肾细胞癌共存的病例。先前的报告显示了淋巴样肿瘤与实体瘤的关系，但通常描述的是与化疗相关的继发性癌症形式。
