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同步性透明细胞肾细胞癌和经典型霍奇金淋巴瘤。

Synchronous clear cell renal cell carcinoma and classic Hodgkin lymphoma.

作者信息

Christie-Nguyen Phuoc, Ahmed Ahmed A, Ibrahim Nourhan, Armstrong Jacob, Mai Brenda

机构信息

Department of Pathology and Laboratory Medicine The University of Texas Health Science Center at Houston, McGovern Medical School Houston TX USA.

出版信息

IJU Case Rep. 2025 Feb 13;8(3):185-189. doi: 10.1002/iju5.12831. eCollection 2025 May.

DOI:10.1002/iju5.12831
PMID:40336730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12055214/
Abstract

INTRODUCTION

The coexistence of renal cell carcinoma and classic Hodgkin lymphoma is exceedingly rare, with only two documented cases. Here, we present the third case diagnosed in our institution.

CASE PRESENTATION

A 46-year-old man presented with right flank pain, fever, mild pancytopenia, and renal mass on computed tomography scan, suggesting renal malignancy. Despite intravenous antibiotics and extensive workup for recurrent fever, his condition did not improve. A bone marrow biopsy revealed rare large EBV-positive B cells. Surprisingly, imaging only showed minimal intraabdominal lymphadenopathy in the perinephric region. Subsequent surgery confirmed clear cell renal cell carcinoma in the kidney and scattered large, atypical cells consistent with classic Hodgkin lymphoma in the suprahilar lymph node.

CONCLUSION

This case presents a rare case of classic Hodgkin lymphoma occurring in the perirenal region. When clinicians encounter unexplained symptoms in patients with primary tumors, additional biopsies should be considered for possible secondary malignancy.

摘要

引言

肾细胞癌与经典型霍奇金淋巴瘤并存极为罕见，仅有两例文献记载。在此，我们报告在我院诊断出的第三例病例。

病例介绍

一名46岁男性因右侧腰痛、发热、轻度全血细胞减少，且计算机断层扫描显示肾脏有肿块，提示为肾恶性肿瘤。尽管静脉使用了抗生素并对反复发热进行了全面检查，但其病情并未改善。骨髓活检发现罕见的大型EBV阳性B细胞。令人惊讶的是，影像学检查仅显示肾周区域有极小的腹内淋巴结肿大。随后的手术证实肾脏存在透明细胞肾细胞癌，肾门上方淋巴结有散在的大型非典型细胞，符合经典型霍奇金淋巴瘤。

结论

本病例呈现了一例罕见的发生于肾周区域的经典型霍奇金淋巴瘤。当临床医生遇到原发性肿瘤患者出现无法解释的症状时，应考虑进行额外活检以排查可能的继发性恶性肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf92/12055214/22579f67dc36/IJU5-8-185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf92/12055214/180c1514386d/IJU5-8-185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf92/12055214/734f444cb7c2/IJU5-8-185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf92/12055214/22579f67dc36/IJU5-8-185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf92/12055214/180c1514386d/IJU5-8-185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf92/12055214/734f444cb7c2/IJU5-8-185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf92/12055214/22579f67dc36/IJU5-8-185-g003.jpg

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