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上消化道良性黏膜类天疱疮:肾细胞癌罕见的副肿瘤综合征表现

Benign mucous membrane pemphigoid of the upper aero-digestive tract: rare paraneoplastic syndrome presentation in renal cell carcinoma.

作者信息

Saravanan K, Baer S T, Meredith A, Dyson A, von der Werth Jan

机构信息

Department of ENT, Conquest Hospital, Hastings, UK.

出版信息

J Laryngol Otol. 2006 Mar;120(3):237-9. doi: 10.1017/S0022215106000193.

Abstract

Benign mucous membrane pemphigoid is a rare autoimmune disorder affecting the upper aero-digestive tract and conjunctivae. This is a case presentation of benign mucous membrane pemphigoid affecting the oral mucosa, pharynx, oesophagus and larynx, leading to cicatricial lesions in the pharynx and larynx, causing dysphagia, hoarseness and stridor. The alternative forms of management for laryngeal scarring due to this disease are explained. The patient was later diagnosed with advanced renal cell carcinoma, raising the possibility of cicatricial pemphigoid manifesting as a paraneoplastic syndrome of underlying renal cell carcinoma.

摘要

良性黏膜类天疱疮是一种罕见的自身免疫性疾病,可累及上呼吸道消化道和结膜。本文介绍了一例累及口腔黏膜、咽、食管和喉的良性黏膜类天疱疮病例,该病例导致咽部和喉部出现瘢痕性病变,引起吞咽困难、声音嘶哑和喘鸣。文中解释了针对该疾病所致喉部瘢痕的其他治疗方式。该患者后来被诊断为晚期肾细胞癌,这增加了瘢痕性类天疱疮作为潜在肾细胞癌副肿瘤综合征表现的可能性。

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