Dermatology Hospital of Jiangxi Province, Jiangxi Provincial Clinical Research Center for Skin Diseases, Candidate Branch of National Clinical Research Center for Skin Diseases, Dermatology Institute of Jiangxi Province, The Affiliated Dermatology Hospital of Nanchang University, Nanchang 330001, China.
Department of Laboratory Medicine, Chronic Disease Research Center, Medical College, Dalian University, Dalian 116622, China.
Biomolecules. 2022 Oct 12;12(10):1461. doi: 10.3390/biom12101461.
Anti-laminin (LM) 332-type mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease and was originally discovered as anti-epiligrin cicatricial pemphigoid. Anti-LM332-type MMP has clinical manifestations similar to those of other types of MMP and can only be distinguished through the detection of circulating autoantibodies against LM332. Our group and others have established a number of immunological methods with varying sensitivity and specificity for detection of anti-LM332 autoantibodies; however, none of the established methods has been widely used for clinical diagnosis. There is currently no unified standard treatment, and it is very difficult to completely cure anti-LM332-type MMP. In addition, an increasing body of evidence suggests that there may be a strong correlation between anti-LM332-type MMP and tumors. In this article, we review the current progression of diagnosis and treatment of anti-LM332-type MMP, as well as the possible correlation between anti-LM332-type MMP and tumors.
抗层粘连蛋白 (LM) 332 型黏膜性大疱性皮病 (MMP) 是一种罕见的自身免疫性大疱性疾病，最初被发现为抗桥粒芯糖蛋白 1 型的瘢痕性类天疱疮。抗 LM332 型 MMP 的临床表现与其他类型的 MMP 相似，只能通过检测针对 LM332 的循环自身抗体来区分。我们的研究小组和其他研究小组已经建立了许多具有不同灵敏度和特异性的免疫方法来检测抗 LM332 自身抗体；然而，目前尚无一种已建立的方法被广泛应用于临床诊断。目前还没有统一的标准治疗方法，要完全治愈抗 LM332 型 MMP 非常困难。此外，越来越多的证据表明，抗 LM332 型 MMP 与肿瘤之间可能存在很强的相关性。本文综述了抗 LM332 型 MMP 的诊断和治疗的最新进展，以及抗 LM332 型 MMP 与肿瘤之间可能存在的相关性。
