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[寻常型天疱疮与上呼吸道及食管良性瘢痕性黏膜类天疱疮]

[Pemphigus vulgaris and benign cicatricial mucous membrane pemphigoid in the upper respiratory tract and esophagus].

作者信息

Jørgensen B G, Pedersen A T, Gjertsen B T

机构信息

Vejle Sygehus, øre-, naese- og halsafdelingen.

出版信息

Ugeskr Laeger. 1993 Jul 5;155(27):2126-9.

PMID:8328063
Abstract

Pemphigus vulgaris and benign cicatricial membrane pemphigoid are both autoimmune, blistering, dermatologic diseases characterised clinically by tense bullae on skin or on mucous membranes. Both diseases are rare, but very serious, associated with a high death rate (pemphigus) or high morbidity with cicatricial mucosal lesions (pemphigoid) if untreated. These diseases are discussed and two case stories mentioned where the primary focus was in the upper aerodigestive tract, which is very seldom. The otolaryngologist can make an important contribution to the early recognition, diagnosis, and management of these diseases. The biopsy must undergo immunofluorescence examination.

摘要

寻常型天疱疮和良性瘢痕性类天疱疮均为自身免疫性水疱性皮肤病,临床上表现为皮肤或黏膜上的紧张性大疱。这两种疾病均罕见,但非常严重,若不治疗,寻常型天疱疮死亡率高,类天疱疮则会导致瘢痕性黏膜病变发病率高。本文对这些疾病进行了讨论,并提及了两个主要累及上气道消化道的病例,这种情况非常少见。耳鼻喉科医生对这些疾病的早期识别、诊断及管理可做出重要贡献。活检必须进行免疫荧光检查。

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