Parilla B V, Endres L K, Dinsmoor M J, Curran L
Department of Obstetrics, Section of Maternal-Fetal Medicine, Lutheran General Hospital, Park Ridge, IL 60068, USA.
Int J Gynaecol Obstet. 2006 May;93(2):106-9. doi: 10.1016/j.ijgo.2006.01.026. Epub 2006 Mar 20.
To evaluate the progression in utero of mild isolated fetal ventriculomegaly (defined as a transverse diameter of the atrium of the lateral ventricle measuring between 10 and 15 mm), and to estimate the proportion of fetuses that normalize (diameter decreasing to less than 10mm), stabilize (remaining between 10 and 15 mm), or progress to more severe ventriculomegaly (becoming greater than 15 mm).
The obstetric databases of 3 institutions were queried for any studies mentioning ventriculomegaly or hydrocephalus. Reports and original images were reviewed to verify cases of isolated mild ventriculomegaly, with no other anomalies on comprehensive ultrasonographic examination. Fetuses that had 2 or more evaluations more than 3 weeks apart were included.
A total of 63 fetuses met the criteria for isolated mild ventriculomegaly. The mean gestational age and ventricular measurements were 24.7+/-3.7 weeks and 11.8+/-1.1mm, respectively, at the initial scan and 34+/-2.9 weeks and 12.1 +/-3.8mm, respectively, at the final scan. The mean number of scans was 3.75 per fetus (range, 2-6). Amniocentesis revealed the deletion of 5p, which causes the cri du chat, in 1 of 21 fetuses; 26 fetuses (41%) showed normalization of the lateral ventricles; 10 fetuses (16%) showed progression; and 27 (43%) appeared stable. shows the statistics of the individual groups. Three of the fetuses that "stabilized" improved from 15 mm to 11, 11.5, and 11.7 mm, respectively. Two worsened from 10.2 to 14 mm and from 11.4 to 13 mm.
More than 40% of the cases of mild isolated fetal ventriculomegaly resolved in utero. The significant overlap in measurements for the different groups precludes prediction in individual cases. However, of the 13 cases where the transverse diameter measured 13 mm or more, only 1 normalized, while 9 of the remaining 12 cases stabilized and 3 progressed.
评估轻度孤立性胎儿脑室扩大（定义为侧脑室房部横径在10至15毫米之间）在子宫内的进展情况，并估计脑室大小恢复正常（直径降至小于10毫米）、保持稳定（维持在10至15毫米之间）或进展为更严重脑室扩大（直径大于15毫米）的胎儿比例。
查询3家机构的产科数据库，查找任何提及脑室扩大或脑积水的研究。查阅报告和原始图像，以核实孤立性轻度脑室扩大病例，这些病例在全面超声检查中无其他异常。纳入间隔超过3周进行了2次或更多次评估的胎儿。
共有63例胎儿符合孤立性轻度脑室扩大标准。初次扫描时的平均孕周和脑室测量值分别为24.7±3.7周和11.8±1.1毫米，末次扫描时分别为34±2.9周和12.1±3.8毫米。每个胎儿的平均扫描次数为3.75次（范围为2至6次）。羊水穿刺显示，21例胎儿中有1例存在导致猫叫综合征的5p缺失；26例胎儿（41%）侧脑室恢复正常；10例胎儿（16%）病情进展；27例胎儿（43%）病情稳定。显示了各个组别的统计数据。“病情稳定”的胎儿中有3例分别从15毫米改善至11毫米、11.5毫米和11.7毫米。2例分别从10.2毫米恶化至14毫米和从11.4毫米恶化至13毫米。
超过40%的轻度孤立性胎儿脑室扩大病例在子宫内得到缓解。不同组别的测量值存在显著重叠，无法对个体病例进行预测。然而，在横径测量为13毫米或更大的13例病例中，只有1例恢复正常，其余12例中有9例病情稳定，3例病情进展。
