Oliver D W, Dekker T G, Snyckers F O
Department of Pharmaceutical Chemistry, Pretoria College of Pharmacy, University of Pretoria, Republic of South Africa.
Arzneimittelforschung. 1991 May;41(5):549-52.
Two amino derivatives of (D3)-Trishomocubanes recently synthesized were evaluated for their in vivo and in vitro activities against selected viruses. Both these derivatives exhibited promising in vivo activity against Herpes simplex Type II and Influenza A2/Taiwan, comparable with aciclovir and amantadine, respectively. No in vitro activity was observed for both compounds against Herpes simplex Types I and II and Rhinovirus 1A.
最近合成的两种（D3）-三高立方烷的氨基衍生物针对选定病毒进行了体内和体外活性评估。这两种衍生物均对II型单纯疱疹病毒和甲型流感病毒A2/台湾株表现出有前景的体内活性，分别与阿昔洛韦和金刚烷胺相当。两种化合物对I型和II型单纯疱疹病毒以及鼻病毒1A均未观察到体外活性。
