单纯疱疹病毒1型缺陷干扰颗粒不影响阿昔洛韦、膦甲酸和阿糖腺苷的抗病毒活性。
Herpes simplex type 1 defective interfering particles do not affect the antiviral activity of acyclovir, foscarnet and adenine arabinoside.
作者信息
Harmenberg J G, Svensson L T
机构信息
Department of Virology, National Bacteriological Laboratory, Stockholm, Sweden.
出版信息
Acta Virol. 1988 Mar;32(2):153-5.
PMID:2899962
Abstract
The concentration of defective interfering particles (DI-particles) of herpes simplex type 1 virus was analysed by electron microscopy and plaque titration. Fifteen consecutive passages of undiluted virus in green monkey kidney cells were followed. No relationship was found between the concentration of DI-particles and the activity of antiviral substances such as acyclovir, foscarnet and adenine arabinoside.
摘要
采用电子显微镜和蚀斑滴定法对1型单纯疱疹病毒缺陷干扰颗粒（DI颗粒）的浓度进行了分析。对未稀释的病毒在绿猴肾细胞中连续传代15次进行了跟踪观察。未发现DI颗粒浓度与阿昔洛韦、膦甲酸钠和阿糖腺苷等抗病毒物质的活性之间存在关联。
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