Kelley Darshan S, Rasooly Reuven, Jacob Robert A, Kader Adel A, Mackey Bruce E
U.S. Department of Agriculture/ARS, Western Regional Research Center, Department of Nutrition, University of California, Davis, CA 95616, USA.
J Nutr. 2006 Apr;136(4):981-6. doi: 10.1093/jn/136.4.981.
The purpose of this study was to determine the effects of consuming sweet cherries on plasma lipids and markers of inflammation in healthy humans. Healthy men and women (n = 18) supplemented their diets with Bing sweet cherries (280 g/d) for 28 d. After a 12-h fast, blood samples were taken before the start of cherry consumption (study d 0 and 7), 14 and 28 d after the start of cherry supplementation (study d 21 and 35), and 28 d after the discontinuation (study d 64) of cherry consumption. After cherries were consumed for 28 d, circulating concentrations of C-reactive protein (CRP), regulated upon activation, normal T-cell expressed, and secreted (RANTES), and NO decreased by 25 (P < 0.05), 21 (P < 0.05), and 18% (P = 0.07) respectively. After the discontinuation of cherry consumption for 28 d (d 64), concentrations of RANTES continued to decrease (P = 0.001), whereas those of CRP and NO did not differ from either d 7 (pre-cherries) or d 35 (post-cherries). Plasma concentrations of IL-6 and its soluble receptor, intercellular adhesion molecule-1, and tissue inhibitor of metalloproteinases-2 did not change during the study. Cherry consumption did not affect the plasma concentrations of total-, HDL-, LDL-, and VLDL- cholesterol, triglycerides, subfractions of HDL, LDL, VLDL, and their particle sizes and numbers. It also did not affect fasting blood glucose or insulin concentrations or a number of other chemical and hematological variables. Results of the present study suggest a selective modulatory effect of sweet cherries on CRP, NO, and RANTES. Such anti-inflammatory effects may be beneficial for the management and prevention of inflammatory diseases.
本研究的目的是确定食用甜樱桃对健康人体血脂和炎症标志物的影响。健康男性和女性（n = 18）在其饮食中补充宾莹甜樱桃（280克/天），持续28天。禁食12小时后，在开始食用樱桃前（研究第0天和第7天）、开始补充樱桃后14天和28天（研究第21天和第35天）以及停止食用樱桃后28天（研究第64天）采集血样。食用樱桃28天后，C反应蛋白（CRP）、活化调节正常T细胞表达和分泌因子（RANTES）的循环浓度以及NO分别下降了25%（P < 0.05）、21%（P < 0.05）和18%（P = 0.07）。停止食用樱桃28天（第64天）后，RANTES的浓度继续下降（P = 0.001），而CRP和NO的浓度与第7天（食用樱桃前）或第35天（食用樱桃后）相比没有差异。在研究期间，血浆中白细胞介素-6及其可溶性受体、细胞间黏附分子-1和金属蛋白酶组织抑制剂-2的浓度没有变化。食用樱桃不影响总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇、甘油三酯、高密度脂蛋白亚组分、低密度脂蛋白亚组分、极低密度脂蛋白亚组分的血浆浓度及其颗粒大小和数量。它也不影响空腹血糖或胰岛素浓度以及许多其他化学和血液学变量。本研究结果表明甜樱桃对CRP、NO和RANTES具有选择性调节作用。这种抗炎作用可能对炎症性疾病的管理和预防有益。
