正常和转化的培养细胞中肌动蛋白和肌球蛋白的组织模式。
Patterns of organization of actin and myosin in normal and transformed cultured cells.
作者信息
Pollack R, Osborn M, Weber K
出版信息
Proc Natl Acad Sci U S A. 1975 Mar;72(3):994-8. doi: 10.1073/pnas.72.3.994.
The patterns of distribution of intracellular actin and myosin were examined by specific immunofluorescence in a series of normal, simian-virus-40-transformed, and revertant cell lines of rat and mouse origin. A consistent correlation was found between sensitivity to anchorage-dependent growth control and the presence of large, thick sheaths of actin-containing material. The presence of these sheaths was temperature-dependent in a rat line transformed by a temperature-sensitive mutant in the complementation group A of the oncogenic virus simian virus 40.
通过特异性免疫荧光法，在一系列源自大鼠和小鼠的正常细胞系、猿猴病毒40（SV40）转化细胞系及回复细胞系中检测细胞内肌动蛋白和肌球蛋白的分布模式。结果发现，对贴壁依赖性生长控制的敏感性与含有肌动蛋白的物质形成的大而厚的鞘的存在之间存在一致的相关性。在由致癌病毒猿猴病毒40的A互补组中的温度敏感突变体转化的大鼠细胞系中，这些鞘的存在是温度依赖性的。
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