Drouet Alain, Smati Salim, Ferrer Marie-Hélène, Martinez Jean-Yves, Guilloton Laurent, Felten Dominique
Service de Neurologie, HIA Desgenettes, Lyon.
Presse Med. 2006 Mar;35(3 Pt 1):418-20. doi: 10.1016/s0755-4982(06)74606-1.
Capnocytophaga canimorsus is a fusiform and filamentous gram-negative rod, part of the normal oral flora of dogs and cause rare human febrile acute meningitis, usually severe but curable.
A sixty years old man presented a severe acute meningitis with fever and confusion. CSF show 4,000 cells/mm3 with 83% neutrophilis, increased protein level (5,02 g/L), very low glucose and positive Gram stain result. The patient fully and quickly recovered with antibiotherapy for 22 days. Bacteriological diagnosis was made by genomic study from CSF culture. The patient has a close contact with his dog without being recently bitten.
Diagnosis, suggested by bites or contact with dog or cat, gram-negative bacilli with gram stain of CSF specimen, is possible by prolonged culture of CSF or blood sample, with if necessary genomic study. Antibioprophylaxis is strongly recommended in cases of deep bite wounds and for immunocompromised patients.
犬咬二氧化碳嗜纤维菌是一种梭形、丝状革兰氏阴性杆菌，是犬正常口腔菌群的一部分，可引起罕见的人类发热性急性脑膜炎，通常病情严重但可治愈。
一名60岁男性出现伴有发热和意识模糊的严重急性脑膜炎。脑脊液显示每立方毫米有4000个细胞，其中83%为中性粒细胞，蛋白水平升高（5.02g/L），葡萄糖水平极低，革兰氏染色结果为阳性。患者通过22天的抗生素治疗完全且迅速康复。通过脑脊液培养的基因组研究做出了细菌学诊断。该患者与他的狗有密切接触，但近期未被咬伤。
根据咬伤史或与狗或猫的接触史、脑脊液标本革兰氏染色显示革兰氏阴性杆菌，通过延长脑脊液或血样培养，并在必要时进行基因组研究，有可能做出诊断。对于深部咬伤伤口和免疫功能低下的患者，强烈建议进行抗生素预防。
