Mangone Carlos A, Genovese Osvaldo, Abel Carlos
Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Vertex. 2006 Jan-Feb;17(65):16-22.
A review of neurotoxics is made, given the low tendency to investigate for chronic exposure to environmental and industrial potential central nervous system toxic substances (heavy metals, insecticides, organic solvents and carbon monoxide) in the history of a patient consulting for behavioral - cognitive complains, and considering the potential overturn of the disease if a correct diagnosis and early treatment is made.
to determine the onset of the cognitive - behavioral features, presentation pattern, diagnosis and treatment of such neurotoxics (NT).
systematized search in Cochrane and Medline reviews, Embase and Lilacs.
chronic exposure to neurotoxics can produce personality changes (sleeping problems, excitation, depression, delusions and hallucinations) as well as cognitive problems (memory, learning, language and cognitive reaction problems). NT may cause changes in the neuron morphology and its sub cellular structures, affecting its normal biochemistry and physiology (proteins and neurotransmitters synthesis). The clinical history, diagnosis and treatment of each neurotoxic are discussed.
The NT must be taken in consideration among the possible different etiologies when a patient with a bizarre behavioral cognitive syndrome is examined.
鉴于在因行为 - 认知主诉前来咨询的患者病史中,对慢性暴露于环境和工业中潜在的中枢神经系统有毒物质(重金属、杀虫剂、有机溶剂和一氧化碳)进行调查的倾向较低,并且考虑到如果做出正确诊断和早期治疗,疾病可能会被扭转,因此对神经毒物进行了综述。
确定此类神经毒物(NT)的认知 - 行为特征的发病情况、表现模式、诊断和治疗方法。
在考克兰系统评价、医学期刊数据库、荷兰医学文摘数据库和拉丁美洲及加勒比地区卫生科学数据库中进行系统检索。
慢性暴露于神经毒物可导致人格改变(睡眠问题、兴奋、抑郁、妄想和幻觉)以及认知问题(记忆、学习、语言和认知反应问题)。神经毒物可能会导致神经元形态及其亚细胞结构发生变化,影响其正常的生物化学和生理学(蛋白质和神经递质合成)。文中讨论了每种神经毒物的临床病史、诊断和治疗方法。
在检查患有怪异行为认知综合征的患者时,必须将神经毒物纳入可能的不同病因之中予以考虑。