Shimizu K, Nakano S, Nakano Y, Ando M, Seki K, Kameda N
Tokyo Rosai Hospital, Japan.
Cancer. 1991 Nov 15;68(10):2284-8. doi: 10.1002/1097-0142(19911115)68:10<2284::aid-cncr2820681030>3.0.co;2-z.
One autopsy case with small cell lung cancer and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is reported. Both plasma atrial natriuretic peptide (ANP) and arginine vasopressin (AVP) levels were high, and the presence of significantly high levels of ANP and AVP in tumor tissue was confirmed by gel chromatography and radioimmunoassay techniques. To the best of the authors' knowledge, this is the first case in which ectopic ANP production and its secretion into blood (leading to SIADH) were proved.
本文报告了一例小细胞肺癌伴抗利尿激素分泌不当综合征（SIADH）的尸检病例。血浆心房利钠肽（ANP）和精氨酸加压素（AVP）水平均升高，通过凝胶色谱法和放射免疫测定技术证实肿瘤组织中存在显著高水平的ANP和AVP。据作者所知，这是首例证实异位产生ANP并分泌入血（导致SIADH）的病例。
