Somanath Payaningal R, Razorenova Olga V, Chen Juhua, Byzova Tatiana V
Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Cell Cycle. 2006 Mar;5(5):512-8. doi: 10.4161/cc.5.5.2538. Epub 2006 Mar 1.
Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the expression and/or activity of various pro- and anti-angiogenic factors and Akt isoforms (Akt1, Akt2 and Akt3) have been proposed as therapeutic targets for angiogenesis-related anomalies such as cancer and ischemic injury.
Akt，也称为蛋白激酶B（PKB），可调节细胞的基本功能，如迁移、增殖、分化、凋亡和代谢。Akt会影响多种促血管生成和抗血管生成因子的表达和/或活性，并且Akt亚型（Akt1、Akt2和Akt3）已被提议作为针对癌症和缺血性损伤等血管生成相关异常的治疗靶点。
