内皮细胞中的Akt1与血管生成
Akt1 in endothelial cell and angiogenesis.
作者信息
Somanath Payaningal R, Razorenova Olga V, Chen Juhua, Byzova Tatiana V
机构信息
Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
出版信息
Cell Cycle. 2006 Mar;5(5):512-8. doi: 10.4161/cc.5.5.2538. Epub 2006 Mar 1.
Abstract
Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the expression and/or activity of various pro- and anti-angiogenic factors and Akt isoforms (Akt1, Akt2 and Akt3) have been proposed as therapeutic targets for angiogenesis-related anomalies such as cancer and ischemic injury.
摘要
Akt，也称为蛋白激酶B（PKB），可调节细胞的基本功能，如迁移、增殖、分化、凋亡和代谢。Akt会影响多种促血管生成和抗血管生成因子的表达和/或活性，并且Akt亚型（Akt1、Akt2和Akt3）已被提议作为针对癌症和缺血性损伤等血管生成相关异常的治疗靶点。
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