紫杉醇在晚期胃癌患者恶性腹水中的药代动力学研究。
Pharmacokinetic study of paclitaxel in malignant ascites from advanced gastric cancer patients.
作者信息
Kobayashi Michiya, Sakamoto Junichi, Namikawa Tsutomu, Okamoto Ken, Okabayashi Takehiro, Ichikawa Kengo, Araki Keijiro
机构信息
Department of Tumor Surgery, Kochi Medical School, Kohasu, Nankoku 783-8505, Japan.
出版信息
World J Gastroenterol. 2006 Mar 7;12(9):1412-5. doi: 10.3748/wjg.v12.i9.1412.
AIM
To examine the paclitaxel concentrations in plasma and ascites after its intravenous administration in patients with ascites due to peritonitis carcinomatosa resulting from advanced gastric cancer.
METHODS
Two patients with ascites due to peritonitis carcinomatosa resulting from gastric cancer were included in this study. The paclitaxel concentrations in plasma and ascites were investigated for 72 h in case 1 and 168 h in case 2 after intravenous administration.
RESULTS
The paclitaxel concentration in plasma peaked immediately after administration, followed by rapid decrease below the threshold value of 0.1 micromol (85 ng/mL) within 24 h. In contrast,the paclitaxel concentration in ascites increased gradually for 24 h after administration to a level consistent with the level found in plasma. After 24 h the level of paclitaxel in ascites and plasma became similar, with the optimal level being maintained up to 72 h following administration.
CONCLUSION
The concentration of paclitaxel in ascites is maintained within the optimal level for the treatment of cancer cells for up to 72 h after intravenous administration. Paclitaxel is a promising drug for the treatment of malignant ascites of gastric cancer.
目的
研究晚期胃癌导致的癌性腹膜炎腹水患者静脉注射紫杉醇后血浆和腹水中紫杉醇的浓度。
方法
本研究纳入两名因胃癌导致癌性腹膜炎腹水的患者。在病例1中静脉注射后72小时以及病例2中静脉注射后168小时，对血浆和腹水中的紫杉醇浓度进行研究。
结果
血浆中紫杉醇浓度在给药后立即达到峰值，随后在24小时内迅速降至低于0.1微摩尔（85纳克/毫升）的阈值。相比之下，腹水中紫杉醇浓度在给药后24小时内逐渐升高至与血浆中浓度一致的水平。24小时后，腹水和血浆中的紫杉醇水平变得相似，给药后长达72小时维持在最佳水平。
结论
静脉注射紫杉醇后，腹水中紫杉醇浓度在长达72小时内维持在治疗癌细胞的最佳水平。紫杉醇是治疗胃癌恶性腹水的一种有前景的药物。
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