Gotoh Minehiro, Li Chang, Yatoh Mariko, Iguchi Akihisa, Hirooka Yoshifumi
Department of Laboratory Medicine, Aichi Medical University School of Medicine, 21-Karimata, Nagakute, Aichi 480-1195, Japan.
Endocr Regul. 2005 Dec;39(4):119-25.
Serum uric acid concentrations in diabetics are well known to be significantly lower than those in non-diabetic subjects, due to increased its urinary clearance. Serum 1,5-anhydroglucitol concentrations are also specifically decreased in diabetics through the increased urinary excretion. To gain an insight into the idea that a common mechanism might be possible to work in reducing these serum substances, this study was conducted.
A total of 121 type 2 diabetic patients, 76 males and 45 females, were studied. Multiple regression analysis was performed to determine the independent association between potential predictor variables (mean blood pressure, body mass index, fasting plasma glucose, glycosylated hemoglobin A1c, serum fructosamine, serum 1,5-anhydroglucitol, serum creatinine, serum total cholesterol, and serum triglycerides) and serum uric acid concentrations as the dependent variable.
In the male subjects, serum 1,5-anhydroglucitol, serum creatinine and body mass index were the variables independently related to serum uric acid concentrations. In the female subjects, serum 1,5-anhydroglucitol and serum creatinine were the variables independently related to serum uric acid concentrations.
Considering the glucosuria-related urinary excretion of 1,5-anhydroglucitol, a close positive association between serum uric acid and 1,5-anhydroglucitol concentrations strongly supports the idea that the reduction in serum uric acid concentrations is mediated by urinary glucose excretion in diabetics.
众所周知，由于糖尿病患者尿酸的尿清除率增加，其血清尿酸浓度显著低于非糖尿病患者。通过增加尿排泄，糖尿病患者的血清1,5 -脱水葡萄糖醇浓度也会特异性降低。为了深入了解可能存在一种共同机制来降低这些血清物质的情况，开展了本研究。
共研究了121例2型糖尿病患者，其中男性76例，女性45例。进行多元回归分析，以确定潜在预测变量（平均血压、体重指数、空腹血糖、糖化血红蛋白A1c、血清果糖胺、血清1,5 -脱水葡萄糖醇、血清肌酐、血清总胆固醇和血清甘油三酯）与作为因变量的血清尿酸浓度之间的独立关联。
在男性受试者中，血清1,5 -脱水葡萄糖醇、血清肌酐和体重指数是与血清尿酸浓度独立相关的变量。在女性受试者中，血清1,5 -脱水葡萄糖醇和血清肌酐是与血清尿酸浓度独立相关的变量。
考虑到与糖尿相关的1,5 -脱水葡萄糖醇的尿排泄，血清尿酸与1,5 -脱水葡萄糖醇浓度之间密切的正相关有力地支持了以下观点：糖尿病患者血清尿酸浓度的降低是由尿葡萄糖排泄介导的。
