Department of Endocrinology, Xuhui District Central Hospital, No. 966, Huaihai Zhong Road, Shanghai 200031, China.
Department of Nephrology, Xuhui District Central Hospital, No. 966, Huaihai Zhong Road, Shanghai 200031, China.
Sci Rep. 2017 Mar 10;7:44291. doi: 10.1038/srep44291.
1,5-anhydroglucitol (1,5-AG), uric acid and urinary proteins are excreted into the urine with increasing glucosuria. In the present retrospective study we analyzed whether these factors could be used as indicators for type 2 diabetes mellitus (T2DM) glucose control in 6,766 (T2DM) patients. There were 3,988 cases (58.9%) with HbA1c ≤ 6.5%, 853 cases (12.61%) with HbA1c levels ranging from 6.5% to 7% and 1,925 cases (28.5%) with HbA1c > 7%. HbA1c percentages were correlated with age, MA and 1,5-AG serum concentrations (P < 0.001). The serum uric acid concentration (P < 0.001) was significantly lower in elevated MA (P < 0.001) and 24-hour urinary protein (P = 0.024) patients. Hb1Ac percentages (P < 0.001) were significantly enhanced in patients with 1,5-AG serum concentrations ≤10 mg/L compared to >10 mg/L. With a derived receiver operating characteristic (ROC) curve, a 1,5-AG cut-off value of 11.55 mg/L for hyperglycemia could be diagnosed with a specificity of 71.2 (69.7-72.6) and a sensitivity of 75.3 (73.6-76.9). The serum 1,5-AG concentration is a marker for hyperglycemia and may be particularly useful as an indicator for short-term glycemic excursions in order to improve treatments in T2DM patients.
1,5-脱水山梨醇（1,5-AG）、尿酸和尿蛋白随葡糖尿的增加而排泄到尿液中。在本回顾性研究中，我们分析了这些因素是否可用于 6766 例（2 型糖尿病）患者的 2 型糖尿病（T2DM）血糖控制指标。其中，HbA1c≤6.5%的有 3988 例（58.9%），HbA1c 水平在 6.5%至 7%之间的有 853 例（12.61%），HbA1c>7%的有 1925 例（28.5%）。HbA1c 百分比与年龄、MA 和 1,5-AG 血清浓度相关（P<0.001）。尿酸浓度（P<0.001）在 MA 升高（P<0.001）和 24 小时尿蛋白升高（P=0.024）患者中显著降低。与 1,5-AG 血清浓度>10mg/L 的患者相比，1,5-AG 血清浓度≤10mg/L 的患者的 Hb1Ac 百分比（P<0.001）显著升高。通过衍生的接受者操作特征（ROC）曲线，可以将 1,5-AG 为 11.55mg/L 作为诊断高血糖的切点，特异性为 71.2%（69.7-72.6），敏感性为 75.3%（73.6-76.9）。血清 1,5-AG 浓度是高血糖的标志物，可特别用于指示短期血糖波动，以改善 T2DM 患者的治疗。
