Department of Internal Medicine, Kinki Central Hospital, Japan.
Clin Chim Acta. 2009 Dec;410(1-2):70-3. doi: 10.1016/j.cca.2009.09.024. Epub 2009 Sep 23.
1,5-Anhydroglucitol is found in food. We determined factors other than glucosuria that affect serum 1,5-anhydroglucitol (1,5-AG) concentration.
The relationships between serum 1,5-AG concentration and metabolic parameters were investigated in 158 males with normal glucose tolerance verified by an oral glucose tolerance test.
Serum uric acid was positively correlated to 2-h plasma glucose and serum 1,5-AG concentrations. Serum 1,5-AG levels were not different between hyperuricemic and normouricemic subjects, though those with normouricemia had lower 2-h plasma glucose concentrations than subjects with hyperuricemia. The association between 1,5-AG and uric acid in serum was still evident after adjustment with 2-h plasma glucose concentration. Multivariate regression analyses demonstrated that serum uric acid was an independent variable related to serum 1,5-AG and vice versa.
1,5-AG and uric acid may share in part a common renal tubular transport system, independent of glucose excretion.
1,5-脱水山梨醇存在于食物中。我们确定了除葡萄糖尿症以外的影响血清 1,5-脱水山梨醇（1,5-AG）浓度的其他因素。
我们对 158 名糖耐量正常的男性（通过口服葡萄糖耐量试验证实）进行了研究，考察了血清 1,5-AG 浓度与代谢参数之间的关系。
血清尿酸与 2 小时血浆葡萄糖和血清 1,5-AG 浓度呈正相关。高尿酸血症和正常尿酸血症患者的血清 1,5-AG 水平无差异，但正常尿酸血症患者的 2 小时血浆葡萄糖浓度低于高尿酸血症患者。在调整 2 小时血浆葡萄糖浓度后，1,5-AG 与血清尿酸之间的相关性仍然明显。多元回归分析表明，血清尿酸是与血清 1,5-AG 相关的独立变量，反之亦然。
1,5-AG 和尿酸可能部分共享一个共同的肾小管转运系统，与葡萄糖排泄无关。
