Close relationship between serum concentrations of 1,5-anhydroglucitol and uric acid in non-diabetic male subjects implies common renal transport system.

BACKGROUND

1,5-Anhydroglucitol is found in food. We determined factors other than glucosuria that affect serum 1,5-anhydroglucitol (1,5-AG) concentration.

METHODS

The relationships between serum 1,5-AG concentration and metabolic parameters were investigated in 158 males with normal glucose tolerance verified by an oral glucose tolerance test.

RESULTS

Serum uric acid was positively correlated to 2-h plasma glucose and serum 1,5-AG concentrations. Serum 1,5-AG levels were not different between hyperuricemic and normouricemic subjects, though those with normouricemia had lower 2-h plasma glucose concentrations than subjects with hyperuricemia. The association between 1,5-AG and uric acid in serum was still evident after adjustment with 2-h plasma glucose concentration. Multivariate regression analyses demonstrated that serum uric acid was an independent variable related to serum 1,5-AG and vice versa.

CONCLUSIONS

1,5-AG and uric acid may share in part a common renal tubular transport system, independent of glucose excretion.