Pinnock C, Shane B, Stokstad E L
Proc Soc Exp Biol Med. 1975 Mar;148(3):710-3. doi: 10.3181/00379727-148-38615.
Evidence is presented that peptide products of hydrolysis of casein, including some di- and tripeptides, but not the constituent amino acids, can stimulate growth of C. briggsae in defined basal medium supplemented with cytochrome C and B-sitosterol. Peptide activity may raise from amino acid imbalances in the medium which causes competitive inhibition of uptake of essential amino acids. Such activity precludes facilitation of heme transport as the sole function of growth factor in C. briggsae. This is the first report in a nutritional role of peptides in invertebrate metazoa.
有证据表明，酪蛋白水解产生的肽产物，包括一些二肽和三肽，但不包括组成氨基酸，能够在添加了细胞色素C和β-谷甾醇的特定基础培养基中刺激布氏秀丽隐杆线虫的生长。肽的活性可能源于培养基中氨基酸的不平衡，这种不平衡会竞争性抑制必需氨基酸的摄取。这种活性排除了促进血红素运输作为布氏秀丽隐杆线虫生长因子唯一功能的可能性。这是关于肽在无脊椎后生动物营养作用的首次报道。
