Skoog S M, Bharucha A E, Camilleri M, Burton D D, Zinsmeister A R
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
Neurogastroenterol Motil. 2006 Apr;18(4):300-6. doi: 10.1111/j.1365-2982.2006.00757.x.
It is unknown if sorbitol, a widely used laxative agent, accelerates colonic transit, and if these effects are modified by concomitant meal ingestion. Colonic transit was assessed by (111)In scintigraphy in 40 healthy subjects. After a 24-h scan, subjects received sorbitol (30 mL of 70% solution) or dextrose (30 mL of 70% solution), administered with or without a meal. Colonic transit, breath hydrogen excretion, and symptom scores were recorded for 4 h thereafter. VAS scores for flatulence, but not other symptoms increased (P = 0.004) by 13.1 +/- 6.3 mm (mean +/- SEM) on a 100 mm scale after sorbitol alone or sorbitol with a meal (by 18.9 +/- 7.2 mm), but not after dextrose. After adjusting for GC(24), sorbitol accelerated (P < 0.001) colonic transit (GC(28) = 3.0 +/- 0.3) compared with dextrose (GC(28) = 2.2 +/- 0.2), regardless of meal ingestion. Breath hydrogen excretion was correlated with the change in colonic transit (r = 0.52, P < 0.01) and with flatulence (r = 0.45, P = 0.003) after sugar ingestion. In healthy subjects, sorbitol accelerated colonic transit and increased flatulence but not other symptoms within 4 h, regardless of meal intake.
目前尚不清楚广泛使用的泻药山梨醇是否会加速结肠运输，以及这些作用是否会因同时进食而改变。通过对40名健康受试者进行铟-111闪烁扫描来评估结肠运输情况。在进行24小时扫描后，受试者接受山梨醇（30毫升70%溶液）或葡萄糖（30毫升70%溶液），给药时有的有进食，有的没有进食。此后记录4小时内的结肠运输、呼气氢排泄和症状评分。单独服用山梨醇或进食时服用山梨醇后，在100毫米量表上，肠胃胀气的视觉模拟评分（VAS）增加（P = 0.004），增加了13.1±6.3毫米（平均值±标准误）（进食时服用山梨醇增加了18.9±7.2毫米），而服用葡萄糖后则没有增加。在对24小时结肠运输时间进行校正后，与葡萄糖（28小时结肠运输时间=2.2±0.2）相比，无论是否进食，山梨醇均加速了结肠运输（P < 0.001）（28小时结肠运输时间=3.0±0.3）。进食糖后，呼气氢排泄与结肠运输的变化相关（r = 0.52，P < 0.01），与肠胃胀气相关（r = 0.45，P = 0.003）。在健康受试者中，无论是否进食，山梨醇在4小时内都会加速结肠运输并增加肠胃胀气，但不会增加其他症状。
