Beaugerie L, Lémann M, Jian R, Flourié B, Rain J D, Rambaud J C
INSERM U 290, Unité de Recherche sur les Fonctions Intestinales, le Métabolisme et la Nutrition, Hôpital Saint-Lazare, Paris, France.
Neurogastroenterol Motil. 1996 Sep;8(3):235-9. doi: 10.1111/j.1365-2982.1996.tb00262.x.
The aim of our study was to test the hypothesis that the better absorption of sorbitol when ingested with glucose could be related to a delayed gastric emptying. We tested the effect of the ingestion of glucose and lipids on the gastric emptying and intestinal absorption of sorbitol in six healthy volunteers, using gastric scintigraphy and hydrogen breath test. After an overnight fast, subjects ingested in random order, on 48-h test periods separated by at least one week, the following solutions: (a) 20 g sorbitol alone; (b) 20 g sorbitol and 20 g glucose; (c) 20 g sorbitol and 9 g lipids. Isotopic acquisitions were taken for 3 h following the ingestion of sorbitol labelled with 111Indium. Hydrogen concentration was measured in end-expiratory samples during 5 h, and the areas under the breath hydrogen curve, reflecting the amounts of sorbitol unabsorbed in the small bowel, were compared between periods. Mean area under the curve was 397 +/- 159 when sorbitol was ingested alone, and this was significantly lower when ingested with glucose or lipids (313 +/- 181 and 337 +/- 135, respectively; P < 0.05). The three curves of sorbitol gastric emptying differed significantly from each other, the gastric emptying being the slowest for sorbitol plus lipids, and the fastest for sorbitol taken alone. We found a positive correlation between the half-emptying time and the hydrogen areas under the curve (r = 0.46, P = 0.05). In conclusion, our study demonstrates that adding glucose or lipids to a solution of sorbitol slows the gastric emptying of sorbitol, resulting in a better intestinal absorption of sorbitol.
山梨醇与葡萄糖一起摄入时吸收更好，这可能与胃排空延迟有关。我们使用胃闪烁扫描和氢呼气试验，测试了葡萄糖和脂质摄入对6名健康志愿者胃排空及山梨醇肠道吸收的影响。在禁食过夜后，受试者在至少相隔一周的48小时测试期内随机摄入以下溶液：(a) 单独摄入20克山梨醇；(b) 20克山梨醇加20克葡萄糖；(c) 20克山梨醇加9克脂质。摄入用铟-111标记的山梨醇后，进行3小时的同位素采集。在5小时内测量呼气末样本中的氢气浓度，并比较各测试期反映小肠中未吸收山梨醇量的呼气氢气曲线下面积。单独摄入山梨醇时，曲线下平均面积为397±159，与葡萄糖或脂质一起摄入时该面积显著降低（分别为313±181和337±135；P<0.05）。山梨醇的三条胃排空曲线彼此差异显著，山梨醇加脂质时胃排空最慢，单独摄入山梨醇时最快。我们发现半排空时间与曲线下氢气面积之间存在正相关（r = 0.46，P = 0.05）。总之，我们的研究表明，在山梨醇溶液中添加葡萄糖或脂质会减缓山梨醇的胃排空，从而使山梨醇在肠道中的吸收更好。
