体外干扰素产生的增强：泰洛龙-聚rL:rC/DEAE-葡聚糖的一种特性。
Enhancement of interferon production in vitro: a property of tilorone-poly rL:rC/DEAE-Dextran.
作者信息
Groelke J W, Camyre K P, Mayer G D
出版信息
Proc Soc Exp Biol Med. 1975 Apr;148(4):1044-7. doi: 10.3181/00379727-148-38685.
PMID:165541
Abstract
Tilorone and Poly rI:rC, in the presence of DEAE-dextran, were found to exhibit a marked synergism with respect to the induction of interferon in L929 and primary mouse embryo fibroblasts, but not human foreskin fibroblasts, in cell cultures. The degree of synergism was proportional to the concentrations of tilorone and Poly rI:rC and was influenced by the times of addition of the compounds relative to each other.
摘要
在细胞培养中，发现泰洛龙和聚肌苷酸:聚胞苷酸（Poly rI:rC）在二乙氨基乙基葡聚糖（DEAE - 葡聚糖）存在的情况下，对于在L929细胞和原代小鼠胚胎成纤维细胞中诱导干扰素表现出显著的协同作用，但在人包皮成纤维细胞中则没有。协同作用的程度与泰洛龙和聚肌苷酸:聚胞苷酸的浓度成正比，并且受到这两种化合物相互添加时间的影响。
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