Kandefer-Szerszeń M, Meczyński S, Borowska L, Szuster-Ciesielska A, Rzeski W
Department of Applied Microbiology, M. Curie-Skłodowska University, Lublin, Poland.
Arch Immunol Ther Exp (Warsz). 1994;42(5-6):425-31.
Interferon production in spotted sousliks in different physiological states: in summer activity, summer torpor, winter hibernation and awaked from winter hibernation was studied. Three different interferon inducers: poly rI:rC complexed with DEAE-dextran, lipopolysaccharide from E. coli (LPS) and tilorone hydrochloride were used. In comparison with sousliks active in summer, the interferon levels in serum and different organs of sousliks in winter hibernation after induction with tilorone hydrochloride, LPS and poly rI:rC were significantly lower. Decreased interferon response was also observed in sousliks in summer torpor and awaked from winter hibernation. In contrast to hibernation, artificial acidosis induced by placing sousliks in the atmosphere with a high concentration of CO2 enhanced interferon production.
研究了不同生理状态下（夏季活动期、夏季蛰伏期、冬季冬眠期以及从冬季冬眠中苏醒后）花栗鼠体内干扰素的产生情况。使用了三种不同的干扰素诱导剂：与二乙氨基乙基葡聚糖复合的聚肌苷酸:聚胞苷酸复合物、大肠杆菌脂多糖（LPS）以及盐酸泰洛龙。与夏季活跃的花栗鼠相比，用盐酸泰洛龙、LPS和聚肌苷酸:聚胞苷酸诱导后，冬季冬眠花栗鼠血清和不同器官中的干扰素水平显著降低。在夏季蛰伏期和从冬季冬眠中苏醒的花栗鼠中也观察到干扰素反应降低。与冬眠相反，将花栗鼠置于高浓度二氧化碳环境中诱导的人工酸中毒可增强干扰素的产生。
