Leavy Justine, Ambrosini Gina, Fritschi Lin
School of Population Health, University of Western Australia, Crawley, Western Australia 6009, Australia.
BMC Public Health. 2006 Mar 24;6:75. doi: 10.1186/1471-2458-6-75.
Three decades after US and Australian forces withdrew from Vietnam, there has been much public interest in the health consequences of service in Vietnam. One controversial question is whether the risk of prostate cancer amongst Vietnam veterans is increased. This paper examines relationships between military history, family history and risk of prostate cancer in a population-based case control study.
Cases were selected from the Cancer Registry of Western Australia as incident cases of histologically-confirmed prostate cancer, and controls were age-matched and selected from the Western Australian electoral roll. Study participants were asked to report any military service history and details about that service.
Between January 2001 and September 2002, 606 cases and 471 controls aged between 40-75 years were recruited. An increased prostate cancer risk was observed in men reporting they were deployed in Vietnam although this was not statistically significant (OR = 2.12; 95% CI 0.88-5.06). An increased risk was also observed in men reporting prostate cancer in fathers (OR = 1.90; 95% CI 1.20-3.00) or brothers (OR = 2.05; 95% CI 1.20-3.50) diagnosed with prostate cancer.
These findings support a positive association between prostate cancer and military service history in the Vietnam war and a first degree relative family history of prostate cancer.
在美国和澳大利亚军队从越南撤出三十年之后，公众对在越南服役所带来的健康后果产生了浓厚兴趣。一个有争议的问题是，越南退伍军人患前列腺癌的风险是否增加。本文在一项基于人群的病例对照研究中，考察了军事史、家族史与前列腺癌风险之间的关系。
病例从西澳大利亚癌症登记处选取，为经组织学确诊的前列腺癌新发病例，对照则按年龄匹配，从西澳大利亚选民名册中选取。研究参与者被要求报告任何军事服役史及该服役的详细情况。
在2001年1月至2002年9月期间，招募了年龄在40 - 75岁之间的606例病例和471例对照。报告曾被部署到越南的男性中观察到前列腺癌风险增加，尽管这在统计学上不显著（比值比 = 2.12；95%置信区间0.88 - 5.06）。报告父亲（比值比 = 1.90；95%置信区间1.20 - 3.00）或兄弟（比值比 = 2.05；95%置信区间1.20 - 3.50）被诊断患有前列腺癌的男性中也观察到风险增加。
这些发现支持前列腺癌与越南战争中的军事服役史以及前列腺癌一级亲属家族史之间存在正相关。
