从EB病毒永生化B细胞系培养上清液中亲和纯化得到的可溶性FcεRII/CD23，可在兔体内引起单相热。
Affinity-purified soluble Fc epsilon RII/CD23 derived from a culture supernatant of an EBV-immortalized B-cell line induced a monophasic fever in rabbits.
作者信息
Ghaderi A A, Stanworth D R
机构信息
Department of Microbiology and Immunology, Medical School, Shiraz University, Iran.
出版信息
Immunology. 1991 Aug;73(4):510-1.
Abstract
A soluble form of Fc epsilon RII/CD23 is spontaneously released from most lymphoblastoid cell lines established by the Epstein-Barr virus (EBV). Such a product was purified on an IgE-Sepharose column and its pyrogenic effect was investigated in rabbits. This preparation induced a monophasic fever in rabbits, with a peak response appearing 75 min after injection. Since IgE was found to be capable of abrogating such an effect, it is suggested that IgE might be involved in the control of the effectiveness of this soluble protein.
摘要
一种可溶性形式的FcεRII/CD23可从大多数由爱泼斯坦-巴尔病毒（EBV）建立的淋巴母细胞系中自发释放。这种产物在IgE-琼脂糖柱上进行了纯化，并在兔子身上研究了其致热作用。该制剂在兔子身上引起单相发热，注射后75分钟出现峰值反应。由于发现IgE能够消除这种作用，因此提示IgE可能参与控制这种可溶性蛋白的有效性。
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本文引用的文献
1
Pathogenesis of fever.发热的发病机制。
Physiol Rev. 1960 Jul;40:580-646. doi: 10.1152/physrev.1960.40.3.580.
2
Molecular basis of fever in humans.人类发热的分子基础。
Am J Med. 1982 May;72(5):799-819. doi: 10.1016/0002-9343(82)90548-4.
3
Studies on the mechanism of fever accompanying delayed hypersensitivity. The role of the sensitized lymphocyte.迟发型超敏反应伴发热机制的研究。致敏淋巴细胞的作用。
J Exp Med. 1972 May 1;135(5):1113-32. doi: 10.1084/jem.135.5.1113.
4
Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1.同源干扰素诱导22K因子与内源性热原和白细胞介素-1有关。
Nature. 1985;314(6008):266-8. doi: 10.1038/314266a0.
5
Use of synthetic peptides in the production and characterization of antibodies directed against predetermined specificities in rat immunoglobulin E.
Mol Immunol. 1986 Feb;23(2):181-91. doi: 10.1016/0161-5890(86)90041-6.
6
Interleukin 6 is involved in interleukin 1-induced activities.白细胞介素6参与白细胞介素1诱导的活性。
Eur J Immunol. 1988 Jun;18(6):957-9. doi: 10.1002/eji.1830180619.
7
Interleukin 5 enhances interleukin 4-induced IgE production by normal human B cells. The role of soluble CD23 antigen.白细胞介素5增强正常人B细胞由白细胞介素4诱导的IgE产生。可溶性CD23抗原的作用。
Eur J Immunol. 1988 Jun;18(6):929-35. doi: 10.1002/eji.1830180615.
8
Fever and acute phase response induced in rabbits by human recombinant interferon-gamma.人重组γ干扰素在兔体内诱导的发热和急性期反应。
J Physiol. 1987 Oct;391:209-18. doi: 10.1113/jphysiol.1987.sp016734.
9
Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes.人重组白细胞介素4可诱导正常人单核细胞表达FcεR2/CD23。
J Exp Med. 1988 Apr 1;167(4):1406-16. doi: 10.1084/jem.167.4.1406.
10
Soluble CD23 is released by B lymphocytes cycling in response to interleukin 4 and anti-Bp50 (CDw40).
Eur J Immunol. 1988 Mar;18(3):349-53. doi: 10.1002/eji.1830180305.
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