Salter Sharon A, Batra Ritu S, Rohrer Thomas E, Kohli Neeraj, Kimball Alexa B
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
J Invest Dermatol. 2006 Aug;126(8):1745-8. doi: 10.1038/sj.jid.5700258. Epub 2006 Mar 23.
Pelvic relaxation, a weakening of pelvic support structures, is an under-reported condition that affects a multitude of women. In the United States alone, more than 338,000 procedures for prolapse are performed annually. Decreased collagen content has been noted in the tissues of women affected by this condition. Interestingly, biopsy specimens of women with striae also show a diminution of collagen. Using self-reported anonymous data, we compared the prevalence of striae in women with and without pelvic relaxation to see if an association between these two disorders of connective tissue existed. More than half the women with prolapse (54.7%) (n = 41) reported striae, whereas only 25.0% of women in the non-prolapse group (n = 8) reported striae (P < 0.01). Multivariate logistic regression analysis confirmed striae as a significant risk factor for the development of clinical prolapse (odds ratio 3.12, P < 0.05). There appears to be a strong association between the presence of striae and the development of pelvic relaxation, which is unrelated to conventionally cited risk factors, such as age, weight, number of pregnancies, or postmenopausal status.
盆腔松弛是指盆腔支持结构的弱化，这是一种报告不足但影响众多女性的病症。仅在美国，每年就有超过33.8万例脱垂手术。受此病症影响的女性组织中已发现胶原蛋白含量降低。有趣的是，有妊娠纹的女性活检标本也显示胶原蛋白减少。我们使用自我报告的匿名数据，比较了有盆腔松弛和无盆腔松弛女性的妊娠纹患病率，以确定这两种结缔组织疾病之间是否存在关联。超过一半的脱垂女性（54.7%）（n = 41）报告有妊娠纹，而无脱垂组中只有25.0%的女性（n = 8）报告有妊娠纹（P < 0.01）。多因素逻辑回归分析证实妊娠纹是临床脱垂发生的一个重要危险因素（比值比3.12，P < 0.05）。妊娠纹的存在与盆腔松弛的发生之间似乎存在很强的关联，这与传统上提到的危险因素如年龄、体重、妊娠次数或绝经后状态无关。
