Elbuluk Nada, Saizan Autumn L, Hurtado Arielle Carolina Mora, Hamilton Ted, Kang Sewon
Department of Dermatology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Arch Dermatol Res. 2025 Mar 18;317(1):592. doi: 10.1007/s00403-025-04050-z.
Striae distensae (SD) are a common condition, which can appear differently across skin colors and for which effective treatments remain limited. SD have several risk factors, including pregnancy, obesity, growth spurts, and several pathologic conditions. Few studies have examined whether there are skin color differences regarding SD in their clinical presentation, risk factors, and associated comorbidities. To evaluate the clinical features, risk factors, and associated comorbidities of SD among Black and White women. This was a two-part study involving a telephone questionnaire followed by an in-person clinical assessment with standardized photographs. One hundred forty-three women (75 Black, 68 White) completed the survey, and 66 women (33 Black, 33 White) completed the in-person clinical assessment. Black and White women in the study were found to be similar in age, SD duration, parity, pregnancy-associated weight gain, and family history. Black women, on average, had a greater number of SD than White women (118 versus 76, p = 0.01). Striae were typically white and skin-colored among Black women, but white and violaceous among White women (p = 0.02). Black women were more likely to have involvement of the lower legs (p = 0.04), axilla (p = 0.05), and buttocks (p = 0.002) than White women. Compared to Black women, urinary incontinence was more commonly reported among White women, though this did not reach statistical significance (p = 0.07). There was a significant association between smoking and SD in White women (p = 0.003), but not in Black women. Additionally, Black women were more likely to use creams to diminish the appearance of their striae. While the etiology, prevalence, and risk factors of SD may be similar between Black and White women, there may be important skin color differences in SD clinical features and medical comorbidities. Larger studies are needed to further characterize the relationship between SD and medical comorbidities such as urinary incontinence and pelvic floor dysfunction. The study of this relationship may advance understanding of SD pathogenesis and provide pathways for targeted therapies. More studies are needed to determine the role of SD evaluation as a screening tool to help predict the risk of the development of pelvic floor dysfunction.
膨胀纹（SD）是一种常见病症，在不同肤色人群中表现各异，且有效的治疗方法仍然有限。SD有多种风险因素，包括怀孕、肥胖、生长突增以及一些病理状况。很少有研究探讨在SD的临床表现、风险因素和相关合并症方面是否存在肤色差异。为了评估黑人和白人女性中SD的临床特征、风险因素和相关合并症。这是一项分为两部分的研究，首先进行电话问卷调查，随后进行标准化照片的面对面临床评估。143名女性（75名黑人，68名白人）完成了调查，66名女性（33名黑人，33名白人）完成了面对面临床评估。研究发现，参与研究的黑人和白人女性在年龄、SD病程、产次、孕期体重增加和家族史方面相似。黑人女性平均比白人女性有更多的SD（118条对76条，p = 0.01）。黑人女性的膨胀纹通常为白色和肤色，而白人女性的膨胀纹为白色和紫红色（p = 0.02）。与白人女性相比，黑人女性小腿（p = 0.04）、腋窝（p = 0.05）和臀部（p = 0.002）出现膨胀纹的可能性更大。与黑人女性相比，白人女性更常报告有尿失禁情况，不过这未达到统计学显著性（p = 0.07）。吸烟与白人女性的SD之间存在显著关联（p = 0.003），但与黑人女性无关。此外，黑人女性更有可能使用乳膏来减轻膨胀纹的外观。虽然黑人和白人女性中SD的病因、患病率和风险因素可能相似，但在SD的临床特征和医学合并症方面可能存在重要的肤色差异。需要开展更大规模的研究，以进一步明确SD与诸如尿失禁和盆底功能障碍等医学合并症之间的关系。对这种关系的研究可能会加深对SD发病机制的理解，并为靶向治疗提供途径。需要更多研究来确定SD评估作为一种筛查工具在帮助预测盆底功能障碍发生风险方面的作用。
