Kondo Tetsuo, Ezzat Shereen, Asa Sylvia L
Department of Pathology, University Health Network and Toronto Medical Laboratories, Department of Laboratory Medicine and Pathology, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.
Nat Rev Cancer. 2006 Apr;6(4):292-306. doi: 10.1038/nrc1836.
Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent advances have improved our understanding of its pathogenesis; these include the identification of genetic alterations that activate a common effector pathway involving the RET-Ras-BRAF signalling cascade, and other unique chromosomal rearrangements. Some of these have been associated with radiation exposure as a pathogenetic mechanism. Defects in transcriptional and post-transcriptional regulation of adhesion molecules and cell-cycle control elements seem to affect tumour progression. This information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets.
甲状腺癌是少数发病率正在上升的恶性肿瘤之一。最近的进展增进了我们对其发病机制的理解；这些进展包括识别出激活涉及RET-Ras-BRAF信号级联的共同效应通路的基因改变，以及其他独特的染色体重排。其中一些与辐射暴露作为发病机制有关。黏附分子和细胞周期控制元件的转录和转录后调控缺陷似乎会影响肿瘤进展。这些信息可提供强大的辅助诊断工具，也可用于识别新的治疗靶点。
