Chen Jih-Jung, Peng Chien-Fang, Huang Hung-Yi, Chen Ih-Sheng
Department of Pharmacy, Tajen University, Pingtung, Taiwan, People's Republic of China.
Planta Med. 2006 Apr;72(5):473-7. doi: 10.1055/s-2005-916253.
A new benzopyran, (S)-3-hydroxygarcibenzopyran, and three new biphenyls, garcibiphenyl C, garcibiphenyl D, garcibiphenyl E, together with thirteen known compounds have been additionally isolated from the root of Garcinia linii. The structures of these new compounds were determined through spectral analyses. Among the isolates, 1,7-dihydroxy-3-methoxyxanthone and 1,5-dihydroxy-3-methoxyxanthone showed antitubercular activities with MICs of 3.1 +/- 0.5 and 6.3 +/- 1.0 microg/mL against Mycobacterium tuberculosis 90-221,387 in vitro, respectively.
从线枝藤黄的根中又分离出一种新的苯并吡喃，即（S）-3-羟基藤黄苯并吡喃，以及三种新的联苯，藤黄联苯C、藤黄联苯D、藤黄联苯E，还有13种已知化合物。这些新化合物的结构通过光谱分析得以确定。在分离出的化合物中，1,7-二羟基-3-甲氧基呫吨酮和1,5-二羟基-3-甲氧基呫吨酮在体外对结核分枝杆菌90-221,387显示出抗结核活性，其最低抑菌浓度分别为3.1±0.5和6.3±1.0微克/毫升。
