Phukhatmuen Piyaporn, Raksat Achara, Laphookhieo Surat, Charoensup Rawiwan, Duangyod Thidarat, Maneerat Wisanu
Center of Chemical Innovation for Sustainability (CIS) and School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand.
School of Integrative Medicine, Mae Fah Luang University, Chiang Rai 57100, Thailand.
Heliyon. 2020 Apr 25;6(4):e03625. doi: 10.1016/j.heliyon.2020.e03625. eCollection 2020 Apr.
Roxb. ex Choisy (Clusiaceae) is a Thai local edible plant, which has been used for the treatment of diabetes. The aim of this study is to discover and identify bioactive compounds related to antidiabetic properties from the leaf extract of . -Glucosidase inhibitory bioassay-guided isolation of the ethyl acetate extract of the leaves of resulted in the isolation and identification of 11 compounds. Of these, a decahydro-1-xanthene derivative, garciniacowone K (), was identified as a novel compound. Their structures were characterized by spectroscopic data and by comparison of their NMR spectroscopic data with those previously reported. All compounds were evaluated for their -glucosidase inhibitory and glucose consumption activities. Compound showed the highest efficacy in inhibiting -glucosidase enzyme and promoting glucose consumption activity by 3T3-L1 cells, with IC values of 0.5 μM and 13.1 μM, respectively, without causing toxicity to cells.
罗克斯伯. 前乔西（藤黄科）是一种泰国当地的可食用植物，已被用于治疗糖尿病。本研究的目的是从[植物名称]的叶提取物中发现并鉴定与抗糖尿病特性相关的生物活性化合物。通过对[植物名称]叶的乙酸乙酯提取物进行α - 葡萄糖苷酶抑制生物测定导向的分离，得到并鉴定了11种化合物。其中，一种十氢 - 1 - 氧杂蒽衍生物，藤黄考酮K（[化合物具体结构]），被鉴定为一种新化合物。它们的结构通过光谱数据以及将其核磁共振光谱数据与先前报道的数据进行比较来表征。对所有化合物进行了α - 葡萄糖苷酶抑制和葡萄糖消耗活性评估。化合物[具体化合物编号]在抑制α - 葡萄糖苷酶和促进3T3 - L1细胞葡萄糖消耗活性方面显示出最高效力，IC值分别为0.5 μM和13.1 μM，且对细胞无毒性。
