Gupta Arti, Pandey Sonia, Yadav Jitendra Singh
Uka Tarsadia University, Maliba Pharmacy College, Gopal Vidhya Nagar, Bardoli, Gujarat, India.
Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, Gujarat, India.
Adv Pharm Bull. 2021 Jan;11(1):10-27. doi: 10.34172/apb.2021.002. Epub 2020 Nov 7.
Tuberculosis (TB) is a contagious disease that has affected mankind. The anti-TB treatment has been used from ancient times to control symptoms of this disease but these medications produced some serious side effects. Herbal products have been successfully used for the treatment of TB. Gold is the most biocompatible metal among all available for biomedical purposes so Gold nanoparticles (GNPs) have sought attention as an attractive biosynthesized drug to be studied in recent years for bioscience research. GNPs are used as better catalysts and due to unique small size, physical resemblance to physiological molecules, biocompatibility and non-cytotoxicity extensively used for various applications including drug and gene delivery. Greenly synthesized GNPs have much more potential in different fields because phytoconstituents used in GNP synthesis itself act as reducing and capping agents and produced more stabilized GNPs. This review is devoted to a discussion on GNPs synthesis with herbs for TB. The main focus is on the role of the natural plant bio-molecules involved in the bioreduction of metal salts during the GNPs synthesis with phytoconstituents used as antitubercular agents.
结核病(TB)是一种影响人类的传染病。抗结核治疗自古以来就被用于控制这种疾病的症状,但这些药物会产生一些严重的副作用。草药产品已成功用于治疗结核病。在所有可用于生物医学目的的金属中,金是生物相容性最好的金属,因此近年来,金纳米颗粒(GNPs)作为一种有吸引力的生物合成药物受到关注,用于生物科学研究。GNPs用作更好的催化剂,由于其独特的小尺寸、与生理分子的物理相似性、生物相容性和无细胞毒性,被广泛用于包括药物和基因递送在内的各种应用。绿色合成的GNPs在不同领域具有更大的潜力,因为用于GNP合成的植物成分本身充当还原剂和封端剂,并产生更稳定的GNPs。本综述致力于讨论用草药合成用于结核病治疗的GNPs。主要重点是在使用植物成分作为抗结核药物合成GNPs的过程中,天然植物生物分子在金属盐生物还原中的作用。